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Muscle Science What it truly is: L-citrulline is usually a non necessary amino acid which is of course produced in the human body and which was first isolated from watermelon, even though malate emanates from malic acid and is also an intermediate on the Krebs cycle - a number of chemical reactions used to launch saved energy from carbohydrates, fats and proteins. http://www.healthmegamart.com/muscle-science/