1 / 29

Huntington’s Disease II: Genetics and cell pathology

Huntington’s Disease II: Genetics and cell pathology. Neurobiology of Disease. 1983 - Gusella, Wexler and colleagues identify locus 1993 - Huntintin cloned, CAG, poly Q repeats identified. Myers 2004 NeuroRx. 1:255-62. Paulson Fischbeck Annu. Rev. Neurosci. 1996 19:79-107. Mutant mice: .

jemma
Download Presentation

Huntington’s Disease II: Genetics and cell pathology

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Huntington’s Disease II: Genetics and cell pathology Neurobiology of Disease

  2. 1983 - Gusella, Wexler and colleagues identify locus 1993 - Huntintin cloned, CAG, poly Q repeats identified

  3. Myers 2004 NeuroRx. 1:255-62.

  4. Paulson Fischbeck Annu. Rev. Neurosci. 1996 19:79-107

  5. Mutant mice:

  6. Rubinsztein 2002

  7. Harjes, Wanker Trends Biochem. Sci. 28:425

  8. Landles,Bates 2004 EMBO Reports 5:958

  9. Landles,Bates 2004 EMBO Reports 5:958

  10. Neurotrophins andReceptors NGF BDNF NT3 NT4/5 NGF BDNF NT3 NT4/5 p75NTR TrkB TrkC TrkA (Adapted from Neet & Campenot, 2001)

  11. Bacquet et al. 2004 J Neurosci. 24:4250-8

  12. Arrasate et al. 2004 Nature 431:805

  13. Fig. 2

  14. Gauthier et al. 2004 Fig. 1

  15. Gauthier et al. 2004 Fig. 1

  16. Schroer 2004

More Related