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Proposed study on HIV and ageing

Proposed study on HIV and ageing. As HIV mortality rates have dropped, an increasing proportion of individuals are living with HIV to older ages Around 15% of individuals accessing HIV care in England and Wales in 2007 were aged >50 years

jennifer-lane
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Proposed study on HIV and ageing

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  1. Proposed study on HIV and ageing • As HIV mortality rates have dropped, an increasing proportion of individuals are living with HIV to older ages • Around 15% of individuals accessing HIV care in England and Wales in 2007 were aged >50 years • There is a need to adapt the management of those living with HIV so that their clinical needs continue to be met • However, virtually nothing is known about the likely health care needs of older HIV-positive persons

  2. Study objective To create a nested, cohort of individuals aged >50 years, attending sites within the UK CHIC study and Dublin HIV cohort to address questions relating to several issues: - Uptake and outcomes of HAART in older individuals - ARV pharmacokinetics - Cardiovascular disease - Bone disease - CNS complications - Musculoskeletal manifestations - Women and the menopause - Sexual behaviour - Social and economic factors - CMV infection in compromising immunity during ageing - Resource utilisation

  3. Proposed methods Nested cohort study within UK CHIC and Dublin HIV Cohort Cases: HIV-positive men and women aged >50 years from participating UK CHIC clinics/Dublin cohort

  4. Proposed methods Nested cohort study within UK CHIC and Dublin HIV Cohort Cases: HIV-positive men and women aged >50 years from participating UK CHIC clinics/Dublin cohort Control group 1: HIV-positive men and women in three age groups (20-30, 30-40 and 40-50 years) attending participating clinics

  5. Proposed methods Nested cohort study within UK CHIC and Dublin HIV Cohort Cases: HIV-positive men and women aged >50 years from participating UK CHIC clinics/Dublin cohort Control group 1: HIV-positive men and women in three age groups (20-30, 30-40 and 40-50 years) attending participating clinics Control group 2: Age-, sex-, ethnicity- and risk-group matched HIV-negative persons (identified from similar clinical settings)

  6. Proposed methods Nested cohort study within UK CHIC and Dublin HIV Cohort Cases: HIV-positive men and women aged >50 years from participating UK CHIC clinics/Dublin cohort Control group 1: HIV-positive men and women in three age groups (20-30, 30-40 and 40-50 years) attending participating clinics Control group 2: Age-, sex-, ethnicity- and risk-group matched HIV-negative persons (identified from similar clinical settings) Fully consented study; no intervention Annual study visits Separately funded sub-studies as necessary (e.g. in-depth study of sexual behaviour)

  7. Visit schedule

  8. Visit schedule

  9. Visit schedule

  10. Current study team Marta Boffito (C&W) Alan Winston (St. Mary’s) Jane Anderson (Homerton) Ian Williams (MMC) Frank Post (Kings) Paddy Mallon (Dublin) Jonathan Elford (City University, epidemiologist) Karen Walker-Bone (Brighton) Arne Akbar (UCL, immunologist) Caroline Sabin (UCL, statistician/epidemiologist)

  11. Questions • Is this a study that patients would be keen to participate in? • If not, what might make it more attractive? • Are there other medical issues that we should include? • How do we identify suitable controls? • Community involvement in study team?

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