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Sohail Sheikh Frost & Sullivan, 2003. Cardiac Diagnostics - Changing Practices Review of key markets in Europe. The Future of Cardiac Testing. Agenda Troponins in Europe - end user feedback Decentralised testing in cardiac diagnostics New and emerging markers Questions Motivation
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Sohail Sheikh Frost & Sullivan, 2003 Cardiac Diagnostics - Changing PracticesReview of key markets in Europe
The Future of Cardiac Testing Agenda • Troponins in Europe - end user feedback • Decentralised testing in cardiac diagnostics • New and emerging markers • Questions Motivation • Troponin usage - how much, how often and how widespread ? • Demand for POCt - what factors effect uptake ? • Emerging markers - How widespread will their use be ?
High Monthly usage per site Sw Fi Sp Fr It Dk % penetration of cTn in acute hosp. Ge 0 No 100 UK Ne Be Low Troponins Usage - 2002
Factors to Consider • COST IMPACT - POCt must have a real impact on cost savings through workflow patterns, ie. impacting on waiting times, hospitalisation and bed stay • TIME SENSITIVE - POCt which target conditions where a rapid result and response outweighs the high sensitivity/performance of lab tests. • PATIENT MANAGEMENT BENEFIT - A POCt allowing real benefits through therapeutic programmes, ie, the availability of routine medication following rapid diagnosis or by allowing constant monitoring of a patient drug regime, and or increase of QALY.
What Markers Make Good POC Tests? PATIENT MANAGEMENT COST IMPACT GLUCOSE STREPA HP TROP TIME SENSITIVE
Cardiac POCt - Challenges & Hurdles • Benefits of troponins still being fully realised • High up-front costs of POCt NOT offset by potential of cost savings • Lack of will amongst non-lab staff • Lack of end user choice
TAM Ge Fr Sp It UK Scan Ne Be End user acceptance of cardiac POCt The Future of POC Testing
End Users and New Markers • Lack of implementation practices - hindering usage • Low usage of BNPs not surprising • hs-CRP - widely researched, but less clinical applications so far • Only one visible company (Mercodia) offering mLDL
Natriuretic Peptides - The New ‘Troponins’ ! • End users unable to differentiate between BNP and proBNP • Growth of proBNP will outpace BNP • 40% of NP market $ will be proBNP by 2005 • Adoption of NPs dictated by platform in use at lab • Over 50% of end users unable to quickly adopt BNP test
And Finally…….. • Have companies forecasted the impact NP use will have on troponin sales? • If a troponin - NP double test panel is recommended, will there be end users jumping from one supplier to another? • What will happen to your supply chain if group purchasing continues?
Thank You - Any Questions? For further information: call: +44 (0)20 7343 8383 email: enquiries@frost.com www.biotech.frost.com