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AREAS OF RESEARCH AND TRAINING UNDERGOING AT ICGEB:

Seminar on The Role of Agricultural Biotechnologies for Production of Bioenergy in Developing Countries FAO Headquarters, Iran Room 12 October 2007.

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AREAS OF RESEARCH AND TRAINING UNDERGOING AT ICGEB:

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  1. Seminar on The Role of Agricultural Biotechnologies for Production of Bioenergy in Developing Countries FAO Headquarters, Iran Room 12 October 2007

  2. "Broadly defined, biotechnology is the manipulation of living organisms to produce goods and services useful to human beings." (From: "Modifying Africa" of F. Wambugu).

  3. Microbial agro-industrial biotechnology stems from the traditional practices and products developed by farmers and their families for use on the farm or in the homestead.These practices can be improved greately by the correct implementation of genetic engineering Ethical concerns: Modern biotechnology is often seen as unnatural, but in fact it relies on most of the same spontaneous processes occuring in nature and leading to improvement through selction THE ICGEB, AT ITS LOCATION OF TRIESTE PROMOTES BASIC AND ADVANCED SCIENTIFIC TRAINING IN THE AREA OF MICROBIAL BIOTECHNOLOGY FOR ITS APPLICATIONS IN AGRO-INDUSTRY.AMONG THE ICGEB MEMBER COUNTRIES SEVERAL AFRICAN COUNTRIESARE ALREADY TAKING ADVANTAGE OF THEICGEB PROGRAMMES (http://www.icgeb.org)

  4. AREAS OF RESEARCH AND TRAINING UNDERGOING AT ICGEB: Utilization of genetically selected yeast strains enriched for particular aminoacids (lysine, methionine) for animal feed, and for cellulose and hemicellulosa digestion. (Microbiology, Trieste) Study of plant growth-promoting bacteria (Pseudomonads). Development of insect and pesticide-resistant crops (N.D.) Studies towards the production of stress (drought)-resistant plants (N.D.)

  5. Areas of Primary concern for Developing Countries • Epidemiology of food-related diseases and genetic susceptibilities • Impact of new technologies on food production • Chemical contaminants and pathogens • Safer production and healthier foodstuffs from agriculture • Animal feed and impact on human health • Environmental health risks

  6. ROLE OF TECHNOLOGY PARKS AND INCUBATORS IN TECHNOLOGY TRANSFER Successful experiences in creating technology parks/ incubators providing a basic infrastructure to transform ideas into products and services can serve as model for developing Countries. For example, given the comparative advantage of diversified ethanol production in the world, particular emphasis could be focussed upon research and transformation of agricultural products in such technology parks. It would also be advisable to set up technology parks near existing institutions to attract foreign contract research funds to perform applied research in situ.

  7. Innovation for Development Science Innovation Socialneeds Technology

  8. Food Safety and Health Risks • Background and Aims: • Assuring health and well-being of citizens • Food intake and environmental factors • Safer and health promoting foods • Controlled and integrated production systems • From farm to fork – consumer protection as the driver

  9. Epidemiology of food-related diseases and genetic susceptibility • - Diet, lifestyle and health • - Measuring dietary intake and risk assessment • - Influence of genetic variability

  10. Traceability • Chemical contaminants and pathogens • - Analysis and detection • - Improved prevention and measurement control • - Prion detection, mapping, transfer mechanisms • Safer production and healthier foodstuffs • - Conventional vs. organic vs. GMOs • - Improved animal welfare, husbandry and waste management • Animal feed and impact on human health • Environmental health risks

  11. Respiration (O2 + dispensable mitochondria, r+ , r-, r0) and Fermentation (anaerobic) convert sugars (hexoses): sucrose>fructose>glucose>maltose =CO2 + ethanol

  12. THE ICGEB MANDATE To provide a Centre of excellence for research and training in genetic engineering and biotechnology addressed to developing countries

  13. THE STRUCTURE ICGEB IS ONE CENTRE, MADE OF TWO COMPONENTS AND A NETWORK OF AFFILIATED CENTRES + A NETWORK OF AFFILIATED CENTRES

  14. ICGEB: an intergovernmental organisation 67 Signatory States, 51 Member States, 2 Components: Trieste (Italy) - New Delhi (India) and a network of 35 Affiliated Centres

  15. NEW DELHI COMPONENT

  16. INSTRUMENTS OF ACTION • RESEARCH PROJECTS • LONG TERM TRAINING • SHORT TERM TRAINING • COLLABORATIVE RESEARCH PROGRAMME • COOPERATION WITH INDUSTRIAL SECTOR • SCIENTIFIC SERVICES • INSTITUTIONAL SERVICES

  17. SUMMARY OF THE ACTIVITYOF THE ICGEB (1988-2004) • INTERNATIONAL PUBLICATIONS: 1,220 • LONG TERM FELLOWSHIPS: 481 awarded; 797 MAN/YEARS • SHORT TERM TRAINING: 5,826 persons trained • RESEARCH GRANTS: 232 awarded for a total of US$ 12,163,781.00 • PATENTS: 30 filed • TECHNOLOGY TRANSFER AGREEMENTS: 65 signed

  18. INSTITUTIONAL ACTIVITIES COOPERATION AGREEMENT WITH THE UNITED NATIONS SECRETARIAT. UN AND ICGEB COOPERATE IN ACTIVITIES RELATED TO • SAFE AND SUSTAINABLE USE OF GENETIC ENGINEERING AND BIOTECHNOLOGY • PROTECTION OF BIODIVERSITY • BIOSAFETY AND RISK ASSESSMENT • IMPLEMENTATION OF ARTICLE X OF THE CONVENTION ON BIOLOGICAL DISARMAMENT

  19. MILLENIUM DEVELOPMENT GOALS “THE MILLENNIUM DEVELOPMENT GOALS MAY BE MORE EASILY MET WITH THE EXTENSIVE APPLICATION OF MODERN BIOTECHNOLOGY IN AGRICULTURE AND HEALTH” (Report of the Secretary-General on “Impact of new biotechnologies, with particular attention to sustainable development, including food security, health and economic productivity”- 2003)

  20. GENERAL ASSEMBLY RESOLUTION 58/200 - DECEMBER 2003 TAKES NOTE OF THE PROPOSAL OF THE SECRETARY GENERAL FOR AN INTEGRATED FRAMEWORK FOR BIOTECHNOLOGY DEVELOPMENT WITHIN THE UN SYSTEM AND THE NEED FOR STRENGTHENING CO-ORDINATION BETWEEN THESE RELEVANT ORGANISATIONS AND BODIES IN THE AREA OF BIOTECHNOLOGY

  21. INTER-AGENCY NETWORK FOR CO-OPERATION IN BIOTECHNOLOGY • THE IANCB HAS BEEN ESTABLISHED IN MAY 2004 BY A CLUSTER OF INTERNATIONAL ORGANISATIONS IN ORDER TO: • ELABORATE JOINT STUDIES • STRENGTHEN THE ADVISORY ROLE IN BIOTECHNOLOGY OF THE UN • ASSESS THE IMPACT OF BIOTECHNOLOGY, IN DEVELOPING COUNTRIES • ESTABLISH A COMMON PORTAL FOCUSED ON BIOTECH-RELATED ACTIVITIES LINKED TO THE EXISTING SCIENCE AND TECHNOLOGY DEVELOPMENT NETWORK • ASSIST UNCTAD IN THE PREPARATION OF THE REPORT TO THE UNITED NATIONS GENERAL ASSEMBLY

  22. UN - ICGEB Co-operation Agreement April, 2001 “THE UNITED NATIONS AND THE INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY …CO-OPERATE IN ACTIVITIES RELATED TO THE SUSTAINABLE AND SAFE USE OF GENETIC ENGINEERING AND BIOTECHNOLOGY” ACCORDINGLY, ICGEB IS PRESENTLY CHAIRING THE INTER-AGENCY NETWORK FOR CO-OPERATION IN BIOTECHNOLOGY AND IS TO PLAY A KEY ROLE IN ASSISTING UNCSTD IN THE PREPARATION OF THE REPORT TO THE GENERAL ASSEMBLY.

  23. SCHEMA DEL PROCESSO PILOTA

  24. Modello di criomacinatore a scambio termico (CRISCAT)

  25. BioEthos Project plan : 3 FASI Fase 1: Ricerca Scientifica - ICGEB Ingegnerizzazione dei ceppi di lievito 1.1 produzione ceppi transgenici per digerire la cellulosa in collaborazione con la Piattaforma Nazionale ITSusChem 1.2 ottimizzazione genomica per incrementare la percentuale di etanolo prodotto ad uso industriale; l’ottimizzazione verra’ realizzata tramite l’impiego di tecniche di miglioramento genomico in collaborazione con l’Universita’ di Oxford e grazie ad un sistema sviluppato e brevettato dal laboratorio YMG dell’ICGEB Fase 2: Sviluppo - AREA/Talent Srl/ICGEB Fermentazioni pilota 2.1 Verifica in laboratorio di digestione della cellulosa da materiale criomacerato (ICGEB), sviluppo di sistemi di controllo (Talent Srl) 2.2 sviluppo di impianto pilota con utilizzo di locali dell’AREA di ricerca per lo smaltimento di rifiuti chimici; come ricaduta vi sara’ la creazione di un Centro di Fermentazione (AREA) Fase 3: Implementazione industriale - Cartiere Burgo/Endesa/GasNatural Trasferimento di frigorie 3.1 Utilizzo del freddo prodotto dai rigassificatori (Endesa/GasNatural) per la criomacerazione con conseguente digestione di cellulosa di scarto (Cartiere Burgo) e produzione industriale di BioEtanolo. In questa fase e’ presente il coinvolgimento di distributori petrolchimici.

  26. Tempistica di attuazione del progetto Fasi ICGEB (Oxford) ICGEB ITSusChem Ricerca 1.1 Nuovi lieviti 1.2 Ottimizzazione Talent/ ICGEB/ Reg. FVG? AREA/ Nuovi Partners Sviluppo 2.1 Verifiche 2.2 Imp. Pilota Burgo/ Endesa/ GasNatural/ Db.Petrolchimici Produzione (Implementazione industriale) 3.1 Trasferimento frigorie 0 1 2 3 t(anni)

  27. DIAGRAMMA DI PROCESSO MALIC cippato FASE 1 Pre-trattamento interno Macinazione meccanica Macinazione biogenica Batteri & Lieviti PAD Acido Vanillico

  28. Proposta di Progetto: • Produzione di bioetanolo con lieviti ingegnerizzati, • via fermentazione di derivati vegetali criomacerati • nella regione Friuli Venezia-Giulia • Responsabile: Prof. Carlo V. Bruschi • Head, Yeast Molecular Genetics Group ICGEB • AREA Science Park, Trieste • Department of Genetics and Developmental Biology • University of Salzburg, Austria • Collaboratori: • Dr. Sergio Stibelli • Talent S.r.l, Trieste • Paolo Mander • Sister - Liaison Office • AREA Science Park, Trieste • Dr. Valentina Tosato • Yeast Molecular Genetics Group, ICGEB • Dipartimento di Biofisica UNIGE & • Margburg University, Germany • Regione Friuli Venezia-Giulia • 23 Novembre, 2006

  29. Il sistema BIT per la bioenergia

  30. C

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