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Trypanosoma cruzi

(Assasin Bug). Trypanosoma cruzi. Christopher Ellis. Historical Accounts. In Charles Darwin’s passage from The Voyage of the Beagle , he writes about… His encounter with the Reduvidae bug The size of the bug Blood-sucking process Darwin was also thought to

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Trypanosoma cruzi

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  1. (Assasin Bug) Trypanosoma cruzi Christopher Ellis

  2. Historical Accounts In Charles Darwin’s passage from The Voyage of the Beagle, he writes about… • His encounter with the Reduvidae bug • The size of the bug • Blood-sucking process Darwin was also thought to have been infected by Chagas disease as well!

  3. Historical Development • Originally named Schizotrypanum cruzi by Brazilian physician/infectologist Carlos Chagas in 1909. • First researcher to completely describe a new infectious diseases’ pathogen, vector, host, clinical manifestations, and epidemiology.

  4. Peru, Venezuela, Columbia, Ecuador Panama, Costa Rica Mexico United States Historic Human Migrations of Trypanosoma Cruzi Brazil

  5. Infrastructure of Trypanosoma cruzi consists of… a.) Areas with straw huts, mud walls, and dirt floors b.) Areas with many Assassin bugs • c.) Close proximity to livestock • d.) Poor medical attention among those infected

  6. The Health Care Community’s Responses Medication is effective but… • It is expensive $$$ • Only effective during acute stage of infection • Resistance has already been reported • Agents are toxic with adverse effects A successful vaccine was created in the 1970s but was too expensive!

  7. Prevention • Testing of blood donors • Urbanization • Insecticides • Mosquito nets

  8. 72 % Success of Prevention • 72% of incidence among children and young adults were certified free in Uruguay and Chile. • In Brazil ten out of twelve endemic states were also certified free. 10/12

  9. Anthropogenic Environmental Changes of Trypanosoma cruzi • Urbanization • Spread of host • Deforestation Example: Amazon

  10. Resources • http://www.dbbm.fiocruz.br/tropical/chagas/trypan.html • http://www.cdc.gov/ncidod/dpd/parasites/chagasdisease/factsht_chagas_disease.htm • http://microbewiki.kenyon.edu/index.php/Trypanosoma • http://www.dbbm.fiocruz.br/tropical/chagas/chapter4.html • http://en.wikipedia.org/wiki/Chagas_Disease • http://www.dbbm.fiocruz.br/tropical/chagas/chapter.html • http://www.findarticles.com/p/articles/mi_qa3855/is_199907/ai_n8865783

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