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Sex-Linked Genetics

Sex-Linked Genetics. What are sex chromosomes? X and Y Which sex chromosome is home of most sex-linked traits? X (much larger). Karyotypes: Is this a male or female?. Male. What are examples of traits that are sex-linked?. What are examples of traits that are sex-linked?

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Sex-Linked Genetics

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  1. Sex-Linked Genetics What are sex chromosomes? X and Y Which sex chromosome is home of most sex-linked traits? X (much larger)

  2. Karyotypes:Is this a male or female? Male

  3. What are examples of traits that are sex-linked? What are examples of traits that are sex-linked? 1)Color blindness – (red-green) 2) Hemophilia 3) Muscular Dystrophy 4) Male pattern baldness All are on the X-chromosome

  4. Colorblindness Tests

  5. Should See Circle, Square, star,

  6. Colorblindness

  7. Should see Square, circle

  8. Try to find in the next picture

  9. Dog, Sailboat, balloon, car

  10. Should have seen Faint Brown boat, colorblind individuals would have seen nothing.

  11. Try to see.

  12. Should see Colorblind individuals should see a yellow square. Normal sight should see circle and square.

  13. Ishihara Test http://www.toledo-bend.com/colorblind/Ishihara.html

  14. Hemophilia – blood doesn’t clot Czar Nicholas II of Russia and his family, photographed c. 1916, showing his wife Alexandra (who was a carrier of hemophilia), his four daughters, and (in the foreground) his son Alexis, perhaps the most famous European royal with hemophilia. http://www.humanillnesses.com/original/Gas-Hep/Hemophilia.html

  15. Muscular Dystrophy Muscles form incorrectly, including heart and lungs  death by early 30’s

  16. Male Pattern Baldness Some evidence hints at X linked status Androgens (male sex hormones) play a key role in balding--castrated men don't go bald--and the AR gene helps them do their work. The researchers found the balding men were much more likely to have a particular version of the AR gene than the non-balding men, which they took to mean they'd found a genetic variant that triggers baldness. http://www.straightdope.com/columns/050819.html

  17. Assign letters to each disorder Colorblindness B = normal b = colorblind Hemophilia H = normal h = hemophilia Muscular Dystrophy M = normal m = muscular dystrophy Male pattern baldness P = normal p = male pat. baldness

  18. Fill in this table of phenotypes with the correct genotype XBXB XBY m.d. female XhY Normal (Carrier) female

  19. Fill in this table of phenotypes with the correct genotype XBXB XBY Female with M.D. XhY Normal, carrier female

  20. A normal man and a woman with hemophilia plan on having a baby. 1. Dom = normal Rec= hemophilia 2. H = normal h = hemophilia 3.Mom= XhXh Dad= XHY 4. • 5/6. • Chance of normal = 2/4 • Chance of Carrier = 2/4 • Chance of hemo. = 2/4 Xh Xh XH Y

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