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LOCAL AND HUMORAL CONTROLL OF BLOOD FLOW BY THE TISSUES

Explore the intricate mechanisms governing blood flow control by tissues, including acute and long-term regulation, autoregulation, vascular remodeling, and humoral agents. Discover how factors like oxygen levels, metabolic mechanisms, and specific tissue responses influence circulation.

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LOCAL AND HUMORAL CONTROLL OF BLOOD FLOW BY THE TISSUES

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  1. LOCAL AND HUMORAL CONTROLL OF BLOOD FLOW BY THE TISSUES • MECHANISM OF BLOOD FLOW CONTROLL • I.ACUTE CONTROLL OF LOCAL BLOOD FLOW • A.VASODILATOR THEORY • B.OXYGEN LACK THEORY

  2. METABOLIC MECHANISM • A..REACTIVE HYPEREMIA • B.ACTIVE HYPEREMIA

  3. AUTOREGULATION OF BLOOD FLOW DURING CHANGES IN ARTERIAL PRESSURE 1.METABOLIC MECHANIS M 2.MYOGENIC MECHANISM

  4. Special mechanism for acute blood flow control in specific tissues 1. Kidney : tubuloglomerular feedback mechanism > macula densa located at the jaxtaglomerular apparatus in the kidney. 2. Brain : Increase of CO2 and H ions. 3. Skin : Body temperature .

  5. NO • ROLE OF EDRF (NITIC OXIDE) IN LOCAL CONTROLL OF BLOOD FLOW

  6. LOCAL AND HUMORAL CONTROLL OF BLOOD FLOW BY THE TISSUES • 2.LONG TERM BLOOD FLOW REGULATION • A.CHANGE OF TISSUE VASCULARITY • B.ANGIOGENESIS • C.DEVELOPMENT OF COLLATERAL CIRCULATION

  7. Vascular remodeling in response to chronic changes in blood flow or blood pressure LAPLACE LAW T= r X P T Vascular wall tension r radius P pressure

  8. HUMORAL CONTROL OF CIRCULATION • 1.VASOCONSTRICTOR AGENTS • A.NOREPINEPHRINE AND EPINEPHRINE • B.ANGIOTENSIN II • C.VASOPRESSIN • C.ENDOTHELIN • D.CALCIUM • E.INDIRECT EFFECT OF CO2

  9. HUMORAL CONTROL OF CIRCULATION • 2.VASODILATOR AGENTS • A.BRADYKININ • B.HISTAMINE • C.POTASSIUM,MAGNESIUM ,HYDROGEN AND CO2

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