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Major Histocompatibility complex OR

Major Histocompatibility complex OR. MHC. تفاوت آنتي ژنهاي سازگاري. ساختمانی ژنی توزیع سلولی معرفی نوع پپتید سلول شناسایی کننده. MHC. The principal function of T cells are : Defense against intracellular microbes Activation of other cells(B cells ,Macrophages )

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Major Histocompatibility complex OR

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  1. Major Histocompatibility complexOR MHC

  2. تفاوت آنتي ژنهاي سازگاري ساختمانی ژنی توزیع سلولی معرفی نوع پپتید سلول شناسایی کننده

  3. MHC • The principal function of T cells are : Defense against intracellular microbes Activation of other cells(B cells ,Macrophages ) • peptide recognition by T and B cells is different. B cells recognize soluble as well as cell associated Ags In contrast ,T cells recognize peptide which is displaying only by APC in associated with MHC proteins.

  4. MHC • MHC genes are the most polymorphic genes • MHC genes are codominantly expressed in each individual • There are two main type of MHC:class I & II • The physiologic function of MHC molecules is presentation of peptides to T cells ,control of immune responsiveness to all proteins and graft rejection • MHC-I present cytosolic peptides to T cytotoxic cells and MHC-II present endocytosed peptides to Thcells

  5. MHC –I structure

  6. MHC-II structure

  7. T cell receptor and MHC interaction

  8. Polymorphism of class II • HLA-DPA 12 • HLA-DPB 88 • HLA-DQA 17 • HLA-DQB 42 • HLA-DR >400

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