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Roles of metabolites in muscle fatigue

Roles of metabolites in muscle fatigue. OBJECTIVES Methodology: Experimental approach Temperature Are the changes in metabolites responsible for the decrease in force during fatigu e at the level of the sarcomere. INTRODUCTION. ATP PRODUCTION – METABOLIC PATHWAYS. ATP HYDROLYSIS.

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Roles of metabolites in muscle fatigue

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  1. Roles of metabolites in muscle fatigue OBJECTIVES Methodology: Experimental approach Temperature Are the changes in metabolites responsible for the decrease in force during fatigue at the level of the sarcomere

  2. INTRODUCTION

  3. ATP PRODUCTION – METABOLIC PATHWAYS ATP HYDROLYSIS ATP + H2O ADP + Pi + H+ + WORK CREATINE PHOSPHATE PCr + ADP ATP + Cr ADENYLATE KINASE 2 ADP ATP + AMP PURINE CYCLE AMP + H2O + H+ IMP + NH4+ IMP + ASPARTATE + GTP  ADENYLSUCCINATE + GDP +Pi ADENYLSUCCINATE  AMP + FUMARATE

  4. ATP PRODUCTION – METABOLIC PATHWAYS GLYCOGENOLYSIS AND GLYCOLYSIS GLUCOSYL + 3 ADP + 3 Pi  3 ATP + 3 PYRUVATE GLUCOSE + 2 ADP + 2 Pi  2 ATP + 2 PYRUVATE NO O2 O2 2 LACTATE KREB’S CYCLE & OXYDATIVE PHOSPHORYLATION GLUCOSE + 6 O2 + 36 ADP + 36 Pi  36 ATP + 6 CO2 -OXIDATION FATTY ACID  ACYL-CoAKREB’S CYCLE & OXYDATIVE PHOSPHORYLATION

  5. FATIGUE: FAST & GLYCOLYTIC TWITCH MUSCLE

  6. FATIGUE: SLOW & OXIDATIVE TWITCH MUSCLE

  7. ATP EFFECT ON MAXIMUM SHORTENING VELOCITY

  8. ATP EFFECT ON MAXIMUM FORCE

  9. DISCUSSION

  10. ALL CONCENTRATION IN mM

  11. 0% CO2 15% CO2 WATER 30% CO2

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