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ROLE OF THE MEMBRANE EXCITABILITY IN MUSCLE FATIGUE PART I

ROLE OF THE MEMBRANE EXCITABILITY IN MUSCLE FATIGUE PART I. OBJECTIVES (I and II) Methodology: Electrophysiology: resting Em and action potential Measurement of ion channel activity Control of membrane excitability during muscle activity: Role of ions (Na + , K + and Cl - )

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ROLE OF THE MEMBRANE EXCITABILITY IN MUSCLE FATIGUE PART I

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  1. ROLE OF THE MEMBRANE EXCITABILITY IN MUSCLE FATIGUE PART I OBJECTIVES (I and II) Methodology: • Electrophysiology: resting Em and action potential • Measurement of ion channel activity Control of membrane excitability during muscle activity: • Role of ions (Na+, K+ and Cl-) • Role of Cl- and K+ channels

  2. INTRODUCTION

  3. Lännergren and Westerblad, 1991

  4. Lännergren and Westerblad, 1991

  5. CAFFEINE Lännergren and Westerblad, 1991

  6. PLA: placebo CIT: ingestion of sodium citrate to create an alkalosis

  7. PLA: placebo CIT: ingestion of sodium citrate to create an alkalosis

  8. PLA: placebo CIT: ingestion of sodium citrate to create an alkalosis

  9. DISCUSSION

  10. y = yo e-bx • yo= V/I = Rin (input resistance, from intercept) •  = 1/b (length constant, from slope) • rm = 2 Rin

  11. EDL SOLEUS

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