Poster Draft from Bioengineering’s Capstone Design Course

1. Poster Draft from Bioengineering’s Capstone Design Course

3. Nice background, title bar and headings

4. Too much white space between headings and text in each section. Mission statement should be one sentence; needs emphasis. Increase white space to the left of the text/bullets in this vertical white panel. Bullets and corresponding text should be closer together.

5. Punctuate sentences. Cut “Currently”; emphasize with bold/color: “There is no standardized . . .” “Limited” how?

6. Use different size or bold font to emphasize the difference between regular text and figure caption. Label image and cut caption What about the other prototypes?

7. Word choice? Dimensions? Design doesn’t address this issue. Consider placing Design Objectives before your Solution.

8. Multiple tests for multiple prototypes Use r2; too many sig figs? Tests and results are buried in captions. Separate the testing of prototypes.

9. Lots of space for something not done. Good spacing of bullets here, but use different style for sub-bullets. Avoid jargon. Caption font & line spacing should be smaller.

10. Evidence? Too many words obscure key point. Is it like in the body?

11. Could use smaller font for Acknowledgments and References. Bullets are different sizes. Add Brown Foundation Teaching Grant.

12. Revised poster . . .

13. polyethylene • polyethylene • polyethylene • polypropylenemesh • polypropylenemesh • polyethylene • Load (N) Single Spiral Rice k = 1.2 N/mm Double Spiral DPT k = 0.65 N/mm Single Spiral DPT k = 0.10 N/mm • Deformation (mm) • Load (N) Single Spiral Rice k = 7.3 N/mm Double Spiral DPT k = 0.16 N/mm Single Spiral DPT k = 0.011 N/mm • Deformation (mm) SpiralAT: First Generation Artificial Trachea Team T.I.N.Y., Rice University Theodore John, Insiya Hussain, Nicole Campuzano, and Yoon Kim SpiralAT@aim.com • Mission Statement • We aim to provide the first artificial trachea unit that is ready for immediate implantation through a single-step surgical procedure. • Motivation for SpiralAT • Clinical Significance of Tracheal Replacement • 90% of primary tracheal cancers are malignant. • Of the 90,000 new cases/year of cancers in nearby throat tissues, 25-50% will develop into secondary tracheal cancer. • Other patients suffer from congenital defects and physical trauma. • Current Approaches Sub-optimal • Tracheal resection is limited because reconstruction after resection is not feasible. • Radiation is not fully reliable because studies show inconsistent outcomes in effectiveness. • Case-by-case artificial tracheas have been built, but require multi-staged surgeries that are impractical for patients with urgent needs. • There is no standardized solution. • Design Concept • Design Objectives • Design Components • Synthetic materials allow immediate use. • Helical geometry provides stability and flexibility. • Exterior casing promotes tissue integration. • Solution: The SpiralAT • Mechanical Testing • 3-point bending test • Compression test • Future Work • Biocompatibility Studies in Canines • Quantitative analysis of skin flap integration • by measuring cross-sectional area at the most stenotic point. • Qualitative endoscopy of tissue ingrowth and dehiscence. • Conclusion • Need: Readily implantable, tracheal • replacement performed in a single-step surgery. • Solution: Standardized artificial trachea unit that comprises a polyethylenedouble-helical structure for stability and a polypropylene mesh for good tissue integration. The Double Spiral DPT is the most promising. • Testing: The SpiralAT allows for flexible motion without any permanent deformation or fracture. • Acknowledgements • We’re grateful for the support of Dr. Peirong Yu, Dr. • Michael Liebschner, Dr. Maria Oden, Kevin Bowen, Eugene • Koay, Cain Project, Rice University’s Department of • Bioengineering, and the Brown Foundation Teaching Grant. • References • Glatz F, Neumeister M, Suchy H, Lyons S, Damikas D, Mowlavi A., A tissue-engineering technique for vascularized laryngotracheal reconstruction, Arch Otolaryngol Head Neck Surg. 2003 Feb;129(2):201-6 • Fujiwara T, Maeda M, Kuwae K, Nakagawa T, Nakao K., Free-prefabricated auricular composite graft: a new method for reconstruction following extended hemilaryngectomy, Br J Plast Surg. 2005 Mar;58(2):153-7 • US Dept of Health and Human Services Cancer Statistics 2002 • American Cancer Society 2006 • A) Single Spiral Rice B) Single Spiral DPT C) Double Spiral DPT • Fig. 6. Post-operative examination of an artificial trachea in canine throat • Fig. 1. The three versions of the SpiralAT have different structures and are made of different materials. Each version consists of 2 components, a helical support structure and a shell. • Fig. 2. Simulation of flex/ext using a tennis ball covered crosshead to distribute the force across a wide area of the sample • Fig. 3. Single Spiral Rice was the stiffest, followed by Double Spiral DPT and Single Spiral DPT. Adding an additional helix to the Single Spiral DPT increased stiffness. (crosshead speed=20 mm/min, max extension=10 mm) • Fig. 4. Simulation of flex/ext lateral bending using an angled wedge attached to upper crosshead used to focus compressive force on one side • Fig. 5. Increasing load resulted in elastic deformation. Double Spiral DPT was stiffer than Single Spiral DPT. (crosshead speed=20 mm/min, max extension=10 mm)

14. polyethylene • polyethylene • polyethylene • polypropylenemesh • polypropylenemesh • polyethylene • Load (N) Single Spiral Rice k = 1.2 N/mm Double Spiral DPT k = 0.65 N/mm Single Spiral DPT k = 0.10 N/mm • Deformation (mm) • Load (N) Single Spiral Rice k = 7.3 N/mm Double Spiral DPT k = 0.16 N/mm Single Spiral DPT k = 0.011 N/mm • Deformation (mm) SpiralAT: First Generation Artificial Trachea Team T.I.N.Y., Rice University Theodore John, Insiya Hussain, Nicole Campuzano, and Yoon Kim SpiralAT@aim.com Nice job formulating a mission statement from the original text bullets. Bold text treatment works well. Definition of the problem and affected population is effective. Using red text calls attention to need for standardization, which is one of your primary design goals. Switching the order of the sections devoted to Design Concept and Solution provides a more logical sequence. Great juxtaposition of the images and graphs in Mechanical Testing. However, presenting the results as captions under the graphs diminishes their prominence and makes it harder to determine whether your design achieved what you set out to do. • Mission Statement • We aim to provide the first artificial trachea unit that is ready for immediate implantation through a single-step surgical procedure. • Motivation for SpiralAT • Clinical Significance of Tracheal Replacement • 90% of primary tracheal cancers are malignant. • Of the 90,000 new cases/year of cancers in nearby throat tissues, 25-50% will develop into secondary tracheal cancer. • Other patients suffer from congenital defects and physical trauma. • Current Approaches Sub-optimal • Tracheal resection is limited because reconstruction after resection is not feasible. • Radiation is not fully reliable because studies show inconsistent outcomes in effectiveness. • Case-by-case artificial tracheas have been built, but require multi-staged surgeries that are impractical for patients with urgent needs. • There is no standardized solution. • Design Concept • Design Objectives • Design Components • Synthetic materials allow immediate use. • Helical geometry provides stability and flexibility. • Exterior casing promotes tissue integration. • Solution: The SpiralAT • Mechanical Testing • 3-point bending test • Compression test • Future Work • Biocompatibility Studies in Canines • Quantitative analysis of skin flap integration • by measuring cross-sectional area at the most stenotic point. • Qualitative endoscopy of tissue ingrowth and dehiscence. • Conclusion • Need: Readily implantable, tracheal • replacement performed in a single-step surgery. • Solution: Standardized artificial trachea unit that comprises a polyethylenedouble-helical structure for stability and a polypropylene mesh for good tissue integration. The Double Spiral DPT is the most promising. • Testing: The SpiralAT allows for flexible motion without any permanent deformation or fracture. • Acknowledgements • We’re grateful for the support of Dr. Peirong Yu, Dr. • Michael Liebschner, Dr. Maria Oden, Kevin Bowen, Eugene • Koay, Cain Project, Rice University’s Department of • Bioengineering, and the Brown Foundation Teaching Grant. • References • Glatz F, Neumeister M, Suchy H, Lyons S, Damikas D, Mowlavi A., A tissue-engineering technique for vascularized laryngotracheal reconstruction, Arch Otolaryngol Head Neck Surg. 2003 Feb;129(2):201-6 • Fujiwara T, Maeda M, Kuwae K, Nakagawa T, Nakao K., Free-prefabricated auricular composite graft: a new method for reconstruction following extended hemilaryngectomy, Br J Plast Surg. 2005 Mar;58(2):153-7 • US Dept of Health and Human Services Cancer Statistics 2002 • American Cancer Society 2006 • A) Single Spiral Rice B) Single Spiral DPT C) Double Spiral DPT • Fig. 6. Post-operative examination of an artificial trachea in canine throat • Fig. 1. The three versions of the SpiralAT have different structures and are made of different materials. Each version consists of 2 components, a helical support structure and a shell. • Fig. 2. Simulation of flex/ext using a tennis ball covered crosshead to distribute the force across a wide area of the sample • Fig. 3. Single Spiral Rice was the stiffest, followed by Double Spiral DPT and Single Spiral DPT. Adding an additional helix to the Single Spiral DPT increased stiffness. (crosshead speed=20 mm/min, max extension=10 mm) • Fig. 4. Simulation of flex/ext lateral bending using an angled wedge attached to upper crosshead used to focus compressive force on one side • Fig. 5. Increasing load resulted in elastic deformation. Double Spiral DPT was stiffer than Single Spiral DPT. (crosshead speed=20 mm/min, max extension=10 mm)