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Impact of weight management in chronic HCV Egyptian patients on liver fibrosis .

Explore the influence of weight management on liver fibrosis in Egyptian patients with chronic HCV. Analyzing obesity prevalence, non-invasive fibrosis parameters, diet plan, and its impact on APRI scores. Recommendations for tailored weight management interventions.

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Impact of weight management in chronic HCV Egyptian patients on liver fibrosis .

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  1. Impact of weight management in chronic HCV Egyptian patients on liver fibrosis . By: Dr. Osama A. Fekry Lecturer of CN at the AUC Head of clinical Nutrition department Dar Alshefaa Hospital Master Degree of Tropical Medicine ESPEN Diploma ESGE & ASGE member ASN & ESPEN member ANLP 2010

  2. Liver Cirrhosis in Egypt. • According to the Egyptian ministry of health (2009) statistics mentioned that up to 11 million Egyptian suffers from Viral hepatitis ( C and B). • These patients are of great risk of developing liver cirrhosis ( Portal hypertension) and Hepatocellular carcinoma ( HCC).

  3. Egyptian viral hepatitis burden • Egypt has a very high prevalence of HCV and a high morbidity and mortality from chronic liver disease, cirrhosis, and hepatocellular carcinoma. Approximately 20% of Egyptian blood donors are anti-HCV positive.(WHO). • Approximately 5-7 million Egyptians carry antibodies for HCV and 3.3 million are chronically infected with HBV. (MOHP).

  4. NHTMRI

  5. Obesity epidemic in Egypt. • 34.3 percent of men (aged 15-59) were overweight. • 18.2 percent of men (aged 15-59) were obese. • 28.3 percent of women (aged 15-49) were overweight. • 39.5 percent of women (aged 15-49) were obese. WorldObesity demographic Health Survey 2008

  6. HCV Vs NASH

  7. Non-invasive parameters of Fibrosis • Aminotransferases (ALT-AST) • Platelets. • S. Albumin

  8. Non-invasive parameters of Fibrosis APRI score Regression Progression ≤ 0.7 ≥ F1- F2 F3-F4

  9. Demographic data • 68 HCV obese (naïve) patients enrolled for INF therapy not on any liver support.

  10. Diet plan • We used a weight management programme which was hypocaloric and rich in fibers tailored according to every case . • One plate of Egyptian beans , big plate of salad and at least one serving of fruits per day were common parameters. • In addition to mild exercise.

  11. Comparing parameters before and after diet:

  12. AST / ALT ratio behavior depending on weight loss.

  13. APRI score behavior depending on weight loss.

  14. Impact of diet modification on APRI score

  15. APRI score behavior depending on age group :

  16. APRI score behavior in diabetic patients compared to non diabetic

  17. Conclusion. • Overweight and obesity represented as “Hepatic steatosis” are underestimated risk factors in HCV chronic patients. • Morbid obesity and HCV Can act synergistically with liver fibrosis and fighting each one is not less important than the other .

  18. Recommendations • Weight management programmes (or even bariatric surgeries) should be prescribed to every patient who is HCV +ve and obese.

  19. Thanks

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