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SECOND WEEK. Differentiation of the embryo into three germ layers : Ectoderm . Mesoderm . Endoderm . The Ectoderm will form (1) Central nervous system. (2) Epidermis of Skin. THIRD WEEK. Neural Plate :
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SECOND WEEK Differentiation of the embryo into three germ layers : • Ectoderm. • Mesoderm. • Endoderm. • The Ectodermwill form • (1) Central nervous system. • (2) Epidermis of Skin.
THIRD WEEK • Neural Plate : • It is a dorsal midline thickening of the ectoderm overlying the notochord (Neuroectoderm) .
THIRD WEEK • Neural Folds : • They are the elevated lateral margins of the neural plate. • They are on each side of the longtudinal midline (Neural Groove).
NEURAL TUBE • It is formed from the apposition and fusion of the neural folds which seal the neural groove and create the tube.
FOURTH WEEK • The neural tube is completed and transformed into the adult CNS. • This growth is maximal at the rostral part which becomes the brain. • The caudal portion becomes the spinal cord. • The axis of the neural tube (neuroaxis) is straight.
NEURAL GROOVE • The central cavity within the neural tube becomes : • Ventricles of the brain and • Central canalof the spinal cord.
NEURAL CREST • They are separated cells from the apices of the neural folds. • They are dorsolateral to the neural tube. • They give rise to : • Autonomic ganglia. • Sensory ganglia of spinal and cranial nerves. • Melanocytes. • Cells of supra renalmedulla.
DIFFERENTIATION OF SPINAL CORD • The Grey matter is located centrally around the central canal. • The White matter forms the outer coat.
DIFFERENTIATION OF SPINAL CORD • SulcusLimitans : • It is a longtudinal groove along the inner surface of the lateral walls of the developing spinal cord. • It differentiates the grouping of cells (gray matter) into dorsal (Alar) plate and a ventral (Basal) plate.
DIFFERENTIATION OF SPINAL CORD • The Alar plate is predominantly sensory in function. • The Basal plate is predominantly motor in function.
DIFFERENTIATION OF BRAIN • 5th week: • Three primary brain vesicles appear : • Fore brain (Prosencephalon). • Mid brain (Mesencephalon). • Hind brain (Rombencephalon).
FLEXURES • The neuraxis is bent by two flexures : • Cephalic( Midbrain)flexure at the junction of the fore and mid brains. • Cervical flexure : • Between the brain and spinal cord.
SEVENTH WEEK • Fivesecondary brain vesicles appear.
PROSENCEPHALON • Is divided into : • Telencephalon. • Diencephalon.
TELENCEPHALON • It is the largest brain vesicle. • It has the greatest degree of development. • It forms the two Cerebral Hemispheres.
DIENCEPHALON • It is formed mainly of the Thalamus. • The Thalamus contains numerous groups of neurons and is connected with the cerebral cortex.
ROMBENCEPHALON • Is divided into : • Metencephalon. • Mylencephalon.
PONTINE FLEXURE • It is the third flexure that appears between the metencephalonand the myelencephalon.
METENCEPHALON • It is differentiated into: • Pons . • Cerebellum.
MYELENCEPHALON • It will form : • The Medulla Oblongata.
MESENCEPHALON • It remains undifferentiated. • It is in the form of its embryonic picture : • Central canal surrounded by grey matter.
BRAIN CENTERS • They consist of : • Bilateral paired centers for the senses of : • Smell, Vision,Hearing and • A symmetricalmidlineVestibular center for the maintenance of equilibrium.
BRAIN CENTERS • They start to appear as expansions from the dorsal aspect of the simple tubular brain. • They are composed of an outer cortex of nerve cells with underlying core of nerve fibers.
BRAIN CENTERS • The centers for vision and hearing will form largely automatic, reflex functions. • They are represented by the four colliculi(superior & inferior). • The motor center near the caudal end of the brain will be in the cerebellum.
PROSENCEPHALISATION • The massive cerebral hemispheres which are developed from the rostral (olfactory) part of the brain take an executive role in many functions of the brain.
PROSENCEPHALISATION • They become the highest levels for perception and correlation ofall sensory modalities • They are the highest level for motor control. • The other centers become progressively subservient to the cerebral hemispheres.
CONGENITAL ANOMALIES • (1) Anencephaly • The brain and skull are minute. • It is incompatible for life.
(2) SPINA BIFIDA • It is underdevelopment of the lower part of the spinal cord and the nerve roots. • It may be associated with underdevelopment of the bone and skin.
SPINA BIFIDA • The infants with Spina Bifida complain from : • Paralysed, anesthetic lower limbs. • Incontinence of urine and stool.
(3) MENINGIOMYELOCELE • It is Spina Bifida with • The appearance of the meninges of the spinal cord on the back of the body.