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Non-invasive measurement of the iron overload in the human body

2. Problema medico. Patients suffering from Cooley's anemia (Thalassemia major) need frequent blood transfusions. Transfused red cell iron accumulates in tissues and organs with toxic effects . The most common method for iron evaluation is the liver biopsy. Assessment of body-iron accumulation is essential for managing therapy of iron-chelating diseases characterized by iron overload such as thalassemia, hereditary hemochromatosis, and other forms of severe anemia. .

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Non-invasive measurement of the iron overload in the human body

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    1. 1 Non-invasive measurement of the iron overload in the human body SIF 05 Catania, 09/28/2005

    2. 2 Problema medico

    3. 3 Biosusceptometry

    4. 4 Magnetic moments

    5. 5 Curie law

    6. 6 Iron contribution

    7. 7 SQUID Susceptometer

    8. 8 Susc ratti 1

    9. 9 Susc ratti 2

    10. 10 Magnets and shield

    11. 11 Biosusceptometer

    12. 12 Magnets

    13. 13 Foto magneti e pick-up

    14. 14 IM-IP OM-OP

    15. 15 IM-OP OM-IP

    16. 16 Stretcher

    17. 17 Eddy Current Signal

    18. 18

    19. 19 Phantom

    20. 20 V010

    21. 21 V037

    22. 22 P002 – V005

    23. 23 P002 …therapy

    24. 24 P029 …spleenectomy

    25. 25 P003 12 phlebotomies

    26. 26 Iron overload

    27. 27 The eddy current signal does not depend on the iron

    28. 28 Eddy current and magnetization signals

    29. 29 P029

    30. 30 P002 Statistical Estimate

    31. 31 P003 Statistical Estimate

    32. 32 Measured and calculated magnetization signal of a few volunteers

    33. 33 Errors

    34. 34 Correlation with therapy

    35. 35 Correlation with serum-ferritin

    36. 36 Correlation with SQUID

    37. 37 Referto

    38. 38 Calibration

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