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PRACTICE PATTERNS OF RADIOTHERAPY IN CERVIX CANCER AMONG MEMBER GROUPS OF THE GYNECOLOGIC CANCER INTERGROUP (GCIG)

PRACTICE PATTERNS OF RADIOTHERAPY IN CERVIX CANCER AMONG MEMBER GROUPS OF THE GYNECOLOGIC CANCER INTERGROUP (GCIG).

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PRACTICE PATTERNS OF RADIOTHERAPY IN CERVIX CANCER AMONG MEMBER GROUPS OF THE GYNECOLOGIC CANCER INTERGROUP (GCIG)

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  1. PRACTICE PATTERNS OF RADIOTHERAPY IN CERVIX CANCER AMONG MEMBER GROUPS OF THE GYNECOLOGIC CANCER INTERGROUP (GCIG) D GAFFNEY1, A DU BOIS2, K NARAYAN3, N REED4, T TOITA5, S PIGNATA6, P BLAKE7, L PORTELANCE8, A SADOYZE9, R POTTER10, A COLOMBO11, M RANDALL12, MR MIRZA13, EL TRIMBLE14, 1RTOG, USA  2AGO-OVAR, Germany  3ANZGOG, Australia/New Zealand  4EORTC, Scotland  5JGOG, Japan  6MITO, Italy  7Royal Marsden Hospital, England  8NCIC, Canada  9SGCTG, Scotland  10AGO-AUST, Austria 11MANGO, Italy 12GOG, USA 13NSGO, Scandinavia 14NCI, USA

  2. NSGO Scandinavia SGCTG Scotland MRC (NRCI) AGO-OVAR Germany EORTC NCIC Canada AGO-AUST Austria GINECO France MITO Italy RTOG USA GEICO Spain JGOG Japan MANGO Italy GOG USA ANZGOG Australia/New Zealand

  3. Methods • Survey Developed • Radiotherapy practice • Indications • Doses • Fields • Chemotherapy • Brachytherapy • 4 questionnaires per group • 39 returned from 13 groups • Descriptive statistics

  4. RT Doses 79.1 +/- 7.9 57.9 +/- 5.5 Gy 47.9 +/- 2.9 48.0 +/- 3.5 46.9 +/- 5.1 45.6 +/- 2.7

  5. Total Point A Doses: North America Compared to Other Cooperative Groups 81.8 77.4 Gy p=0.103

  6. Type of Simulation for Definitive RT 1 1 33

  7. Size of Pelvic Field for Definitive RT 8 5 17 4 N=34

  8. IMRT in Definitive RT? N=27

  9. Type of Chemotherapy for Definitive RT? 1 4 2 30 N=37

  10. Dosing of CDDP for Definitive RT (n=30)

  11. Adjuvant Chemo post Hysterectomy and Concurrent ChemoRT N=34

  12. Intervene for a low Hemoglobin 31 N=33

  13. Type of Brachytherapy for Definitive RT 25 N=29

  14. Indications for Para-aortic RT

  15. Upper Border for Para-aortic RT N=31

  16. Vaginal Brachytherapy post Hysterectomy • 18 Rx’d to ½ cm, 8 to Vag surface, 1 to one cm • 23/25 recorded dose to bladder and rectum • 23/27 used HDR • For HDR • Median dose: 17.5 Gy • Median dpf: 6 Gy Degree of Vagina Treated

  17. Conclusions • Radiotherapy Practices among members of GCIG are similar in terms of doses and fields • Concomitant chemotherapy is used by all groups with CDDP predominating • There is no consensus on vaginal brachytherapy prescription • Radiotherapy practices should not be a barrier to intergroup participation in clinical trials

  18. Acknowledgments • Mason Schoenfeldt and Monica Bacon • Executive Board of the GCIG • Respondents • Collegiality among all members

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