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IBS 501 Introduction to Cell Biology Lecture 3 Effectors of RTKs and GPCR signaling;

IBS 501 Introduction to Cell Biology Lecture 3 Effectors of RTKs and GPCR signaling; TGF-  signaling and JAK/STATs Instructor: Karl Saxe Readings: Lodish et al., pages 878-906; 1004-1007; Alberts et al., pages 499-509. OUTLINE 1. Return to Second Messengers a. cAMP and PKA

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IBS 501 Introduction to Cell Biology Lecture 3 Effectors of RTKs and GPCR signaling;

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  1. IBS 501 Introduction to Cell Biology Lecture 3 Effectors of RTKs and GPCR signaling; TGF- signaling and JAK/STATs Instructor: Karl Saxe Readings: Lodish et al., pages 878-906; 1004-1007; Alberts et al., pages 499-509.

  2. OUTLINE 1. Return to Second Messengers a. cAMP and PKA b. IP3/DAG/Ca++ and PLC/PKC c. Nitric Oxide and GC 2. Look at Kinase cascades a. mulitple ways to the same pathway b. multiple kinase cascades 3. Other ways to signal to the nucleus a. TGF--mediated b. JAK/STATs c. NF-B

  3. Second messengers • Hormone stimulation of Gs protein-coupled receptors leads to activation of adenylyl cyclase and synthesis of the second messenger cAMP • cAMP does not function in signal pathways initiated by RTKs, but other second messengers may be initiated by both GPCRs and RTKs • cAMP and other second messengers activate specific protein kinases • cAMP specifically activates cAMP-dependent protein kinases (cAPKs)

  4. CREB links cAMP signals to transcription

  5. Modification of a common phospholipid precursor generates several second messengers: synthesis of DAG and IP3

  6. Synthesis of other phosphoinositides and inositol phosphates from phosphatidylinositol

  7. cGMP mediates local signaling by NO

  8. Signals pass from activated Ras to a cascade of protein kinases

  9. Various types of receptors transmit signals to MAP kinase

  10. Multiple MAP kinase pathways are found in eukaryotic cells

  11. MAP kinase regulates the activity of many transcription factors

  12. 23.1 The TGF signaling pathway Figure 23-3

  13. Phosphorylation-dependent protein degradation regulates NF-B

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