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Cell-Cell Signaling

Cell-Cell Signaling. Neurotransmitters. Ligand-Gated Na + Channel. Post-synaptic membrane. Target Cell. Signal Transduction Pathway of Target Cell. Receptor Tyrosine Kinase-MAP Kinase Pathway. Receptor Tyrosine Kinase (RTK) Activation. (GEF). (RTK). RTKs Bound to Signal Molecule.

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Cell-Cell Signaling

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  1. Cell-Cell Signaling

  2. Neurotransmitters

  3. Ligand-Gated Na+ Channel Post-synaptic membrane

  4. Target Cell

  5. Signal Transduction Pathway of Target Cell

  6. Receptor Tyrosine Kinase-MAP Kinase Pathway

  7. Receptor Tyrosine Kinase (RTK) Activation (GEF) (RTK)

  8. RTKs Bound to Signal Molecule

  9. Activation of Ras Protein Kinase Cascade (GEF)

  10. Kinase Cascade (MKKK) (MKK) Target Proteins

  11. Tumor Progression Pg. 729

  12. Colonize New Tissues Pg. 727

  13. Tumor Growth Pg. 736

  14. Normal Ras and Oncogenic Ras Normal Ras Oncogenic Ras

  15. Post-Translational Modfication of Ras Ras FTase

  16. Therapy for “Ras-Positive” Tumors Ras FTase Inhibitors FTase

  17. Pathways Disrupted in Cancer Cells

  18. Signal Transduction Pathways and Cell Differentiation Stem Cell Specialized cell type (neuron, skin cell, red blood cell, etc.)

  19. Blood Cell Formation

  20. Red Blood Cell Development

  21. EPO Synthesis of proteins that stimulate Red Blood Cell development

  22. Negative Regulation of JAK/STAT Pathway

  23. Cell Types Heart muscle Skeletal muscle Thyroid Ovary Kidney Intestinal epithelia Seven-Pass Receptors Adrenaline Glucogon TSH, LH Contraction Glycogen breakdown Hormone secretion Water retention Ion transport Pg. 546

  24. Activation of Galpha Subunit

  25. Synthesis of cyclic AMP Adenylyl Cyclase ATP cyclic AMP Pg. 550

  26. Targets Ion Channels Transcription Factors Enzymes

  27. Cholera Toxin G.I. Tract G∂ “ON”

  28. Cytoskeletal Structures Intermediate filaments Microtubules Actin Chapter 17

  29. GTP Tubulin Dimer GTP

  30. GFP-Tagged Centrosomes

  31. Centrosome Structure

  32. Microtubule “Poisons” Colchicine Taxol (Autumn crocus) (Pacific Yew)

  33. GTP Tubulin Dimer GTP Taxol

  34. Microtubules Vesicle Transport Chromosome segregation (mitotic spindle) Cilia/Flagella

  35. Microtubule “Motor” Proteins

  36. Microtubule “Motor” Proteins

  37. Actin Filaments

  38. Actin Monomer

  39. Arp2/3 (Actin Related Proteins) Arp2 Arp3

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