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Non-invasive prediction of endometriosis revisited; 3 biomarkers analysis .

Non-invasive prediction of endometriosis revisited; 3 biomarkers analysis. Introduction Endometriosis affects up to 1 in 5 women at their reproductive age group.

jolene-riley
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Non-invasive prediction of endometriosis revisited; 3 biomarkers analysis .

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  1. Non-invasive prediction of endometriosis revisited; 3 biomarkers analysis.

  2. Introduction • Endometriosis affects up to 1 in 5 women at their reproductive age group. • Some immunologic and angiogenic factors e.g. Vascular Endothelial Growth Factor (VEGF), interleukin 1β (IL 1β), angiopoietin-2 (Ang-2) may play a role in the pathogenesis and/or progression of endometriosis

  3. Objective This study was conducted to investigate the serum and Peritoneal fluid (PF) concentrations of (Ang-2), (IL 1β), and (VEGF), aiming to point out any predictive role in endometriosis.

  4. Methods • Blood and peritoneal fluid (PF) samples were taken from 112 women undergoing laparoscopy. • Sixty one were confirmed to have endometriosis and 51 were controls. Measurement in both serum and PF was done using a commercially available enzyme - linked immunosorbent assays (ELISA)

  5. Results • A significant difference was found between patients and controls’ serum and PF concentrations of all except serum IL 1β. • Only PF VEGF was significantly higher in more advanced cases, as well as a positive correlation with the stage of the disease. [Fig.1] • PF and serum VEGF proved an equal and best diagnostic performance with an area under the curve (AUC) for both of 100% (95% CI), followed by PF IL 1β (AUC=73), then serum Ang-2 (AUC=71%), then serum IL 1β (AUC=55%), whereas, PF Ang-2 was the least efficient (AUC=22% ).[Table 1, Fig. 2]

  6. Conclusions • Serum Ang-2, IL 1β, and VEGF, could be reasonable non-invasive predictors of endometriosis. • A “minimally invasive” prediction via peritoneal fluid laparoscopic sampling, especially VEGF, would be a “value-added” to accurate diagnosis. • We, indeed, recommend further studies to probe more markers on a larger number of patients to verify and add to our results.

  7. Thank You

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