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Making Your K Award Application More Attractive

Making Your K Award Application More Attractive. C. A. Hornung, PhD, MPH Professor, Dept. of Epidemiology and Public Health and Professor of Medicine. Bench to Bedside to Community and Back. T-1 Bench to Bedside Proof of Concept. T-2 Bedside to Community Proof in Practice. CERTS.

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Making Your K Award Application More Attractive

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  1. Making Your K Award Application More Attractive C. A. Hornung, PhD, MPH Professor, Dept. of Epidemiology and Public Health and Professor of Medicine

  2. Bench to Bedside to Community and Back T-1 Bench to Bedside Proof of Concept T-2 Bedside to Community Proof in Practice CERTS Pharmacogenomics, Transcriptomics, Metabolomics etc. Therapuetics; EBP; Health Systems, Services And Outcomes Research T-3 “Epi-Omics” e.g., Epi-pharmacogenomics, Epi-transcriptomics, Epi-metabolomics etc.

  3. CORE COMPETENCIES FOR CLINICAL AND TRANSLATIONAL RESEACH SCIENTISTS Conceptualize The Problem Translate the Findings Knowledge of Biomedical, Clinical, Behavioral and Population Sciences Awareness of Health Systems, Cultural Diversity and Health Disparities on HRQoL, Economic Costs and Comparative Effectiveness Scientific Communication: Written and Oral Presentations, Grantsmanship; Tech. Transfer Expert Proficient Competent Data Collection, Data Management; Quantitative and Qualitative Analysis; Bio- and Health Informatics Identify a Testable Translational Research Hypothesis. Novice Beginner Design an Observational or Experimental Study Clinical Operations, Project Management, Budgeting and Finance Measurement of Independent, Dependent and Confounding Variables Leadership, Management and Interdisciplinary Teamwork Ethics; Responsible Conduct of Research; Compliance; Regulatory Affairs; and Scientific Integrity Develop Protocol Perform Study

  4. Education, Training and K Awards: a Strategy for Success • This is what I want to be able to do in 5 years, in 10 years--- • These are the core competencies that I need to master. • I will master the essential core competencies-- • By taking these courses that lead to this degree or certificate • By attending these seminars, workshops, journal clubs, externships, professional/scientific meetings, etc. • By engaging in these professional development activities (e.g., leadership, management, grant writing, public speaking, etc.) • By doing these pilot research projects under my interdisciplinary team of mentors.

  5. My Mentor and Co-Mentors: • Have expertise (i.e., NIH funding) in clinical and basic science appropriate to my project. • Document and describe relevant grant activity (in dept. and university) • Describe access to outside mentors, advisors, collaborators etc and include letters of support. • Have experience mentoring young investigators. • Document and highlight successes (i.e., # publications with trainees, where are trainees employed, # of publications, # grants)

  6. My Mentors • Have resources to support my lab studies and access to an appropriate patient population. • Describe in convincing detail. • Will guarantee protection of >75% or my time to attend class, seminars and conduct my research. • Letters of support from mentor(s), Div. Chief or Dept. Chair • Will further my professional development by including me in grant and manuscript writing, making scientific presentations and participating in IRB, journal, and grant review activities. • Describe in detail in mentoring plan.

  7. Research Support • You must show: • How you will receive training in the responsible conduct of research. • How you have access to clinical epidemiologists and biostatisticians necessary for valid study design, protocol development and sound statistical analysis. • How you have access to CRAs and CRCs to collect reliable (i.e., GCP) clinical and patient data.

  8. K Series Review Criteria Overall Impact Candidate Career Development Plan/Career Goals & Objectives/Plan to Provide Mentoring Research Plan Mentor(s), Co-Mentor(s), Consultant(s), Collaborator(s) Environment and Institutional Commitment to the Candidate

  9. Additional Review Criteria • Training in the Responsible Conduct of Research Reviewers are Required to Comment on • Format • Subject Matter • Faculty Participation • Duration • Frequency

  10. Some Tricks: Write your application with the reviewers in mind!! (Review other K applications and their pink sheets) Consider the Review Template and questions reviewers must answer. Provide a table of abbreviations Provide executive summary tables of each of your mentors productivity and mentoring experience. Have it reviewed >1 month before submission.

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