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Figure 3

Ub. Ub. Ub. Ub. Ub. TNF a. receptor. cytoplasm. adaptor proteins. IKK kinase complex. a. b. IKK complex. NEMO. I k B. NF- k B. 26S proteasome. Phosphorylation of I k B. Ubiquitination and degradation of I k B. NF- k B. ubiquitin. Ub. nucleus. Gene expression.

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  1. Ub Ub Ub Ub Ub TNFa receptor cytoplasm adaptor proteins IKK kinase complex a b IKK complex NEMO IkB NF-kB 26S proteasome Phosphorylation of IkB Ubiquitination and degradation of IkB NF-kB ubiquitin Ub nucleus Gene expression phospho-serine Figure 3

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