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Binding to Complement :  Humoral Immune Answer - Lysis of Opsonized Cells

Binding to Fc Receptors:  Cellular Immune Response - Endocytosis - Secretion of Inflammatory Mediators. Binding to Complement :  Humoral Immune Answer - Lysis of Opsonized Cells. Antibodies are Central Mediators of the Immune Response.

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Binding to Complement :  Humoral Immune Answer - Lysis of Opsonized Cells

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  1. Binding to Fc Receptors:  Cellular Immune Response - Endocytosis - Secretion of Inflammatory Mediators Binding to Complement:  Humoral Immune Answer - Lysis of Opsonized Cells Antibodies are Central Mediators of the Immune Response Huber, R., Deisenhofer, J., Colman, P.M., Matsushima, M., and Palm, W. (1976) Nature 264, 415-420

  2. P6522, a=b=115 Å, c=140 Å, a=b=90°, g=120° FcR/Fc-Wechselwirkung Sondermann, Huber, Oosthuizen, Jacob (2000) Nature 406,267-273

  3. Suppremol • Fc-receptors as therapeutic proteins • in autoimmune diseases • located in Martinsried, Germany • founded in 2003

  4. FcR Fc fragment

  5. Activation Fc-Receptor Specific antibody Antigen Fc-Receptor inhibitor Soluble Fc-Receptor Immune complex Unspecific antibody sFcR as Fc-Receptor Antagonists Inhibition

  6. Soluble-FcR: Proof of Principle inanimal models • Systemic Lupus Erythematodes (NZ B/W) • Rheumatoide Arthritis (Collagen Induced) • Multiple Sclerosis (EAE) • Farmers Lung (Alveolitis)

  7. sFcR bei Autoimmunerkrankungen PBS Tryptophan-Synthase Fc-Rezeptor Überlebensrate Kankheitsindex Fc-Rezeptor Kontolle MS SLE Tage Wochen AK+OVA+sFcR AK+OVA+sFcR AK+OVA AK+OVA AK AK Kontolle Fc-Rezeptor Kankheitsindex PMN x 108 RBC x 108 RA Alveolitis Tage Sondermann, Burkhardt, Schmidt, Linington, Jacob, unveröffentlicht

  8. Structure of the complex of the soluble Fc-receptor and the Fc-fragment of an IgG antibody Huber, R., Deisenhofer, J., Colman, P. M., Matsushima, M. and Palm, W. (1976). Nature264, 415-420. Sondermann, P., Huber, R., Oosthuizen, V. and Jacob, U. (2000).   Nature406, 267-273.

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