1 / 22

Glutamine Losses Due to Continuous Renal Replacement Therapy CRRT in ICU Patients

Questions. Are there elevated losses of glutamine during CRRT?Are glutamine losses higher when supplementation therapy is given?. AB 2004. Primary aim. To measure glutamine losses in the dialysate during CRRT in ICU patients, with and without glutamine supplementation. AB 2004. Secondary aim. To

justis
Download Presentation

Glutamine Losses Due to Continuous Renal Replacement Therapy CRRT in ICU Patients

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

    1. Glutamine Losses Due to Continuous Renal Replacement Therapy (CRRT) in ICU Patients Tidigare studier på friska försökspersoner med hemodialys i 3 timmar har visat dialysen drar 5.8g aminosyror därav 1.6 g glutamin. Normalt födointag av glutamin är ca 5-10g per dag, aminosyror 100-150g per dag. Studier har visat att glutamin är tillgodo till iva pat ökad överlevnad, Griffit, förbättrad outecome för iva pat, van Straaten.Tidigare studier på friska försökspersoner med hemodialys i 3 timmar har visat dialysen drar 5.8g aminosyror därav 1.6 g glutamin. Normalt födointag av glutamin är ca 5-10g per dag, aminosyror 100-150g per dag. Studier har visat att glutamin är tillgodo till iva pat ökad överlevnad, Griffit, förbättrad outecome för iva pat, van Straaten.

    2. Questions Are there elevated losses of glutamine during CRRT? Are glutamine losses higher when supplementation therapy is given? Ja, av ca 3g glutamin rinner ut i dialysatet oavsett om vi ger extra glutamin. Ju högre plasma konc desto mer rinner ut i dialysatet. Molekyl vikt 146.Ja, av ca 3g glutamin rinner ut i dialysatet oavsett om vi ger extra glutamin. Ju högre plasma konc desto mer rinner ut i dialysatet. Molekyl vikt 146.

    3. Primary aim To measure glutamine losses in the dialysate during CRRT in ICU patients, with and without glutamine supplementation

    4. Secondary aim To measure glutamine flux across the leg and glutamine elemination kinetics during CRRT in ICU patients, with and without glutamine supplementation

    5. Under studien gavs inga glutaminhaltiga vätskor parenteralt eller enteralt. Vamin 18 eller Vamin-glukos.Under studien gavs inga glutaminhaltiga vätskor parenteralt eller enteralt. Vamin 18 eller Vamin-glukos.

    6. Under studien gavs inga glutaminhaltiga vätskor parenteralt eller enteralt. Vamin 18 eller Vamin-glukos.Under studien gavs inga glutaminhaltiga vätskor parenteralt eller enteralt. Vamin 18 eller Vamin-glukos.

    7. Under studien gavs inga glutaminhaltiga vätskor parenteralt eller enteralt. Vamin 18 eller Vamin-glukos.Under studien gavs inga glutaminhaltiga vätskor parenteralt eller enteralt. Vamin 18 eller Vamin-glukos.

    8. Under studien gavs inga glutaminhaltiga vätskor parenteralt eller enteralt. Vamin 18 eller Vamin-glukos.Under studien gavs inga glutaminhaltiga vätskor parenteralt eller enteralt. Vamin 18 eller Vamin-glukos.

    9. Under studien gavs inga glutaminhaltiga vätskor parenteralt eller enteralt. Vamin 18 eller Vamin-glukos.Under studien gavs inga glutaminhaltiga vätskor parenteralt eller enteralt. Vamin 18 eller Vamin-glukos.

    22. Conclusion 1(2) There were glutamine losses in the dialysate, which can not be disregarded No difference in glutamine losses in the dialysate related to glutamine supplementation Losses of glutamine during CRRT were 0.6-6.8 g/day The major determinant for the loss of glutamine was the filtration rate Still the loss of glutamine was also related to the plasma concentration of glutamine

    23. The positive whole body glutamine balance during glutamine supplementation was not accompanied by a lower release of glutmine from the leg Consequently glutamine was utilised in tissues other than skeletal muscle, hypothetically in the splancnic area Conclusion 2(2)

More Related