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Ensemble Synchronization in Schizophrenia

Explore the synchronization patterns in schizophrenia using EEG data and ensemble methods. Investigate cross-modal task videos for insight into neural synchronization. Published work with detailed analysis.

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Ensemble Synchronization in Schizophrenia

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  1. Electrical Geodesics Inc & Neuroinformatics Center, UO, 15 Nov. 2013 Ensemble Synchronization in Schizophrenia Kaushik Majumdar, ISI Bangalore Joint work with Pradeep D. Prasad (ISI), John P John (NIMHANS), H. N. Harsha (Nitte University) https://sites.google.com/site/isicng/ (Computational Neuroscience Group)

  2. Video Synchronization: Snapshot

  3. Prasad et al. Clin. EEG Neurosci.44(1): 16 – 24, 2013 Pairwise Hilbert Phase Synchronization

  4. Hilbert Transformation and Instantaneous Phase

  5. Phase Synchronization Prasad et al. 2012

  6. Cross Modal Task

  7. Videos • Healthy control subject http://youtu.be/4aFMQFhiRHw • Patient with schizophrenia http://youtu.be/-TECG5XQhB4

  8. Multi-channel synchronization

  9. Single Trial Ensemble Synchronization

  10. Trial Averaged Ensemble Synchronization

  11. ERSP & ITC

  12. Trial Selection

  13. Classification by Logistic Regression • 3 dimensional feature space: • Ensemble right hemispheric synchronization. • Ensemble left hemispheric synchronization. • Response latency.

  14. 2 Dimensional Projection of 3 Dimensional Feature Space Cross is patient with schizophrenia square is healthy control subject Incongruent stimulus

  15. 2 Dimensional Projection of 3 Dimensional Feature Space Congruent stimulus Plus is patient with schizophrenia circle is healthy control subject

  16. 2 Dimensional Projection of 3 Dimensional Feature Space Neutral stimulus Star is patient with schizophrenia diamond is healthy control subject

  17. Average Accuracy

  18. Probabilistic Score

  19. Reference • P. D. Prasad, H. N. Halahalli, J. P. John and K. Majumdar, “Single-trial EEG classification using logistic regression based on ensemble synchronization,” accepted in IEEE Journal on Biomedical and Health Informatics.

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