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schizophrenia

schizophrenia. negative symptoms. positive symptoms. aggressive symptoms. anx/dep. cognitive symptoms. Stahl S M, Essential Psychopharmacology (2000). 10-1. Positive Symptoms of Schizophrenia. Negative Symptoms of Schizophrenia. Stahl S M, Essential Psychopharmacology (2000). 10-20.

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schizophrenia

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  1. schizophrenia negative symptoms positive symptoms aggressive symptoms anx/dep cognitive symptoms Stahl S M, Essential Psychopharmacology (2000) 10-1

  2. Positive Symptoms of Schizophrenia

  3. Negative Symptoms of Schizophrenia

  4. Stahl S M, Essential Psychopharmacology (2000) 10-20 Functional Status 100% 50% 0 15 20 40 60 Age in years

  5. Basal Ganglia Nucleus accumbens a Substantia nigra c b hypothalamus d Tegmentum Stahl S M, Essential Psychopharmacology (2000) 10-7 DOPAMINE PATHWAYS

  6. Stahl S M, Essential Psychopharmacology (2000) 10-9 mesolimbic overactivity = positive symptoms of psychosis

  7. Mesolimbic Dopaminergic Hyperactivity in Schizophrenia Laruelle et al., Ann NY Acad Sci (2003)

  8. Relationship Between Affinity for Dopamine D2 Receptors and Daily Dose for Treating Schizophrenia

  9. Stahl S M, Essential Psychopharmacology (2000) 10-11 primary dopamine deficiency D2 receptor blockade increase in negative symptoms secondary dopamine deficiency mesocortical pathway

  10. Hypofunction of Mesocortical Dopaminergic Transmission in Schizophrenia Laruelle et al., Ann NY Acad Sci (2003)

  11. Dopamine Dyregulation in Schizophrenia

  12. Glutamate-Dopamine Interactions in Schizophrenia Takahata and Moghaddam, J Neurochem (2000)

  13. Kaplan and Hammer, Am Psychiatric Press Inc, 2002

  14. Thesis- Dopamine Dysregulation in Schizophrenia • Mechanism Schizophrenia Sxs • 1. Hypoactivity of PFC Negative/Cognitive • DA Systems Sxs • 2. Hyperactivity of NAc Positive Sxs • DA Systems • 3. Neuroleptic induced Improves Positive Sxs DA blockade Worsens Negative Sxs

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