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The role of cell clusters in intervertebral disc degeneration and attempted repair response

The role of cell clusters in intervertebral disc degeneration and attempted repair response.

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The role of cell clusters in intervertebral disc degeneration and attempted repair response

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  1. The role of cell clusters in intervertebral disc degeneration and attempted repair response Figure :A) Groups of large sized cell clusters (arrows) around disorganised collagen lamellae in the inner annular region of a degenerated disc, stained with Giemsa. Scale bar 100 µm. B) Higher magnification view of Giemsa stained large sized cell cluster. Scale bar 50 µm. C) H&E stained moderate sized cell cluster. Scale bar 50 µm. Note: One large cluster can contain as many as 60-100 cells within it A B C D E • Figure : D & E ) MMP-1 in its pro and active form in herniated cell cluster (herniated disc upon losing its pressurised confines are free to swell). Scale bar 50µm.

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