The role of cell-Adhesion in inflammation and metastasis

1. The role of cell-Adhesion in inflammation and metastasis 细胞间的黏连在发炎和 癌细胞转移中的作用

2. What is cancer？ Cancer cell 癌症：一种细胞不受正常的生理调节机制控制而无限制增生的疾病。 Cancer is a disease in which cells escape from the body’s normal growth control mechanisms and proliferate in an unregulated manner. Cancer cell

3. Metastasis and metastatic cells The spread of a tumor within the body is called metastasis and is the reason why cancer is such a devastating disease. 肿瘤细胞在体内的传播叫做转移，正因为它癌症才成为了厉害的疾病。 转移细胞，癌细胞开始第二次形成肿瘤。 Metastatic cells，cancer cells that are able to initiate the formation of secondary tumors

4. Metastatic cells must be less adhesive than other cells to break free of the tumor mass. They must be able to penetrate numerous barriers, such as the extracellular matrices of surrounding connective tissue and the basement membranes that line the blood vessels that carry them to distant sites 转移细胞比其他细胞黏着力弱，以便从肿瘤组织中脱离。 转移细胞能穿过多重防护（如组织间的细胞外基质和血管的基底膜）最终到达致病位点。 Differences between metastatic cells and normal cells

5. They must able to invade normal tissues if they are to from secondary colonies. 转移细胞能够侵入正常组织第二次形成肿瘤

6. Two keys of cancer : MMPs E-cadherin Cancer cells

7. MMPs----matrix metalloproteinases(基质金属蛋白) MMPs are enzymes .These enzymes degrade the proteins and proteoglycans that stand in the way of cancer cell migration. In some case, cancer cells secrete their own MMPs ,but in most case growing tumors induce the synthesis and secretion of these enzymes by the surrounding “host” cells. MMPs also appear to stimulate the growth of cancer cells and promote the development of the blood vessels that nourish growing tumors. 基质金属蛋白是一种酶，它可使阻挡癌细胞转移的蛋白质和蛋白聚糖降解。一些癌细胞可自己分泌MMPs，但多数正在生长的肿瘤可促使其“宿主”细胞合成分泌MMPs。 MMPs可刺激癌细胞生长，促进血管产生好进一步滋长新的肿瘤。

8. MMPs----matrix metalloproteinases(基质金属蛋白) Scientist synthesized MMPs inhibitors, it have shown some promise in the treatment of patient with early-stage stomach cancer, but have little promise in stopping late-stage tumor . To date ,the only FDA approved MMP inhibitor is used to treat periodontal <牙周> disease .

9. E-cadherin (上皮-钙黏素) E-cadherin is the predominant cell adhesion molecule of epithelial cells. in one survey of epithelial cell tumors , it was found that the greater the level of expression of E-cadherin, the less the cell’s metastatic potential. 上皮-钙黏素是上皮细胞的重要连接，在对上皮组织细胞瘤的研究中发现E-cadherin表达水平越高，瘤细胞转移潜能越低。 E-cadherin may also inhibit the signaling pathway within the cell that lead to tissue invasion and metastasis.(入侵和转移)

10. thank you ！