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What is going BONE at Nepean?

What is going BONE at Nepean?. A/Prof. Gustavo Duque, MD, PhD, FRACP Director – Geriatric Medicine Section & Ageing Bone Research Program Sydney Medical School Nepean. Aims. Through a bench-bedside-community model: Identifying the mechanisms of age-related bone loss (Basic sciences)

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What is going BONE at Nepean?

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  1. What is going BONE at Nepean? A/Prof. Gustavo Duque, MD, PhD, FRACP Director – Geriatric Medicine Section & Ageing Bone Research Program Sydney Medical School Nepean

  2. Aims • Through a bench-bedside-community model: • Identifying the mechanisms of age-related bone loss (Basic sciences) • Translating research into practice (Clinical sciences) • Developing new diagnostic and treatment strategies for osteoporosis in older persons (Community projects)

  3. Identifying the mechanisms of age-related bone loss (Basic sciences) Duque G, BoneKey-Osteovision, 2008

  4. Identifying the mechanisms of age-related bone loss (Basic sciences) Identified mechanisms: • Lipoapoptosis • Lipotoxicity • Fat vs bone interaction • Dynamics of the nuclear envelope

  5. Identifying the mechanisms of age-related bone loss (Basic sciences) Identified proteins: • Lamin A/C: Nuclear envelope • MAN-1: Nuclear envelope • IDO-1: Tryptophan metabolism • Geranyl Geranyl Transferase: Protein prenylation

  6. Translating research into practice (Clinical sciences)

  7. Translating research into practice (Clinical sciences) • Potential treatments for osteoporosis identified at Nepean (ready for phase II): • Interferon gamma • GGT Inhibitors • PPAR gamma Inhibitor (BADGE)

  8. Translating research into practice (Clinical sciences) • Clinical trials (RCT) • Effect of Zoledronate on Endothelial Dysfunction – The ZED Study • Effect of Vitamin D on Balance in Elderly Fallers – The ViDaBe Study • Cohorts • Quality of Life and Economics in post fracture patients – ECUROS Study • Phase II Tials (starting this October) • Interferon gamma and osteoporosis

  9. Developing new diagnostic and treatment strategies for osteoporosis in older persons (Community projects) • Consensus for the treatment of osteoporosis in long term care (MJA 2010) • Blue Mountains Frailty and Osteoporosis Study (starting this October)

  10. Acknowledgements • Ageing Bone Research Centre-Nepean • Wei Li, PhD • Christopher Vidal, PhD • Krisanthi Gunaratnam • Markus Herrmman, MD, PhD • Derek Boersma • Oddom Demontiero, MD • Victor Chang Institute • Diane Fatkin, PhD • Liz Yeo • Louisiana State University • Jeff Gimble, MD, PhD • Xiying Wu, PhD • Harvard University • Douglas Kiel, MD, MPH • David Karasik, PhD • University of Connecticut • Hicham Drissi, PhD • George Kuchel, MD, PhD • Johns Hopkins University • Jeremy Walston, MD, PhD • Université de Montréal • Pierrette Gaudreau, PhD • Guylaine Ferland, PhD • McGill University • Daniel Rivas, MSc • Richard Kremer, MD, PHD • Alexandre Elbaz • Rahima Akter • Marco Gasparrini • Janet Henderson, PhD • Nepean Medical Research Foundation • University of Sydney-Medical Foundation

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