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The purpose of computing is insight not numbers.“ R. W. Hamming (1962)

The purpose of computing is insight not numbers.“ R. W. Hamming (1962). Angiogenesis: Culprits uncovered The signaling pathway that leads from RAS to MYC culminates in the repression of the key anti-angiogenic factor, thrombospondin-1. Cell, Vol. 104, 333–339, 2001.

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The purpose of computing is insight not numbers.“ R. W. Hamming (1962)

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  1. The purpose of computing is insight not numbers.“ R. W. Hamming (1962)

  2. Angiogenesis: Culprits uncoveredThe signaling pathway that leads from RAS to MYC culminates in the repression of the key anti-angiogenic factor, thrombospondin-1.

  3. Cell, Vol. 104, 333–339, 2001

  4. http://www.signaling-gateway.org/

  5. Watnick, R. S. et al. Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer Cell3, 219–231 (2003)

  6. 6093 7057

  7. Transcription Control

  8. to minimize false positives

  9. to minimize false negatives

  10. Protein-Protein Interaction

  11. The change of the meaning of protein function

  12. Protein-Protein Interaction:Physical Interaction

  13. Gene Ontology • Biological Process • Molecular Function • Cellular Localization

  14. Nature Genetics Vol 25, p25

  15. Nature Biotech 18: p1257

  16. Nature Biotech 18: p1257

  17. PNAS 2001 vol. 98 4277–4278

  18. Protein-Protein Interaction:Function Association

  19. The Rosetta Stone method for detecting functional linkage NATURE VOL 405 , p823, 2000

  20. Phylogenetic ProfilingCurrent Opinion in Chemical Biology 2001, 5:46–50

  21. Gene Order

  22. Protein-Protein InteractionInterologs

  23. InterologsSCIENCE VOL 287 p116

  24. SCIENCE VOL 295 p127

  25. Database • DIP • BIND • GRID

  26. DIP

  27. http://dip.doe-mbi.ucla.edu/

  28. ROCK1 (LocusLink: 6093)

  29. 4869N

  30. BLASTP

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