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Center for Biological Physics

Center for Biological Physics. Lori Goldner, Jenny Ross Adrian Parsegian Direct measurement of intermolecular forces to build a physics of molecular organization Watching single molecules move through channels

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Center for Biological Physics

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  1. Center for Biological Physics Lori Goldner, Jenny Ross Adrian Parsegian Direct measurement of intermolecular forces to build a physics of molecular organization Watching single molecules move through channels Theory of intermolecular forces organizing soft materials, colloids and large bio-molecules

  2. Viral DNA is under pressure that can drive infection: exploded virus and intact virus DNA spooled inside a virus A. Evilevitch,(2006). Bacteriophage T2 Kleinschmidt et al. (1962)

  3. Building a physics of forces and energies for nanometer-to-micrometer - size particles Equation of State: Osmotic pressure vs. DNA density, function of salt, temperature, etc.

  4. Unified equation of state for flexible polymers: Osmotic pressures of many sizes and concentrations fit with ONE parameter. Joel Cohen (Univ Pacific), Rudi Podgornik (Slovenia) To be part-time @UMass

  5. Transport through single ionic channels Current detection of single-molecule transit E(mV) _ I(pA) + 25 µm Detection 1 cm pA 70 µm 0 10 ms Current through channel 100 µm 2 nm Sergey Bezrukov, Philip Gurnev Building an apparatus in Hasbrouck next month

  6. Theory of intermolecular forces(electrostatics, electrodynamics, solvation, steric)example of single-walled carbon nanotubes Connection between dielectric spectra and van der Waals torques/forces. Rick Rajter, Rudi Podgornik, Roger French, Wai-Yim Ching, AP Under study DNA, Lipids (cell membranes), Proteins Xiangyun Qiu, Rudi Podgornik, to be working @UMass Jason DeRouchey, Don Rau, et al. at NIH (where I used to work)

  7. Thanks

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