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Chapter 4

Chapter 4. The Emergence of Neural Fate. d. l. v’. v. PNS Neurons in one Abdominal Hemisegment. Neurogenesis. Proneural gene expression ( achaete, scute ). Proneural cluster. SOP (sensory organ precursor). Lateral inhibition ( Notch, delta ). SOP. Asymmetric cell division

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Chapter 4

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  1. Chapter 4 The Emergence of Neural Fate

  2. d l v’ v PNS Neurons in one Abdominal Hemisegment

  3. Neurogenesis Proneural gene expression (achaete, scute) Proneural cluster SOP (sensory organ precursor) Lateral inhibition (Notch, delta) SOP Asymmetric cell division (numb, Notch) pIIb pIIa neuron socket hair sheath

  4. Sensory organs Proneural genes achaete scute + associated MD neurons + associated MD neurons atonal solo-MD neurons amos

  5. Proneural genes encode basic-helix-loop-helix proteins b HLH achaete 93% 63% scute 26~30% 50% atonal 91% 60% amos

  6. Determination of SOP cells

  7. Regulation of proneural genes

  8. The development of olfactory sensilla coeloconica atonal trichodea amos basiconica From Goulding et al (2000)

  9. Neurogenesis Proneural gene expression (achaete, scute) Proneural cluster SOP (sensory organ precursor) Lateral inhibition (Notch, delta) SOP Asymmetric cell division (numb, Notch) pIIb pIIa neuron socket hair sheath

  10. Neurogenic mutants mutants Wild type

  11. Notch signalinig Delta Notch Su(H) E(spl) E(spl) achaete, scute

  12. Notch signaling pathway leads to downregulation of proneural genes

  13. ES organ SOP hair IIA IIB socket g sheath neuron so h sh n glia Asymmetric Cell Division

  14. Notch SOP Numb Asymmetric localization IIA IIB Numb Cell fate determination

  15. Apical Insc organizer Dlg Lgl Spindle orientation Staufan Prospero mRNA Pon Numb Miranda Prospero Basal

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