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Study populations

Study populations. Hospital-based CRC series (1) (n=196). Population-based CRC series (2) (NLCS) (n=183). CRC patients (n=90). Patients without CRC (n=106). Normal mucosa n=79. Adenoma tissue n=62. CRC tissue n=90. Normal mucosa n=51. Adenoma tissue n=22. Inflamed

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Study populations

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  1. Study populations Hospital-based CRC series (1) (n=196) Population-based CRC series (2) (NLCS) (n=183) CRC patients (n=90) Patients without CRC (n=106) Normal mucosa n=79 Adenoma tissue n=62 CRC tissue n=90 Normal mucosa n=51 Adenoma tissue n=22 Inflamed tissue n=33 Low grade dysplasia n=22 Low grade dysplasia n=54 High grade dysplasia n=8 Crohn disease n=1 Colitis ulcerosa n=5 Diverticulitis n=18 Non specific Inflammation n=9 Supplementary Figure 1. Study population. Of the 90 colorectal cancer patients, carcinoma tissue was collected and, if present, also normal colon mucosa tissue (n=79) and synchronous or metachronous adenoma tissue (n=62). The tissue collected from 106 non-cancerous patients consisted of histologically normal biopsy material (n=51) from patients that underwent endoscopy and did not develop adenomas or colorectal cancer, adenoma biopsy specimens (n=22) from patients who did not develop colorectal cancer within 10 years, and resected colon mucosa from patients with various inflammatory bowel conditions (n=33) who did not develop adenomas or colorectal cancer. CRC = colorectal cancer; NLCS = Netherlands Cohort Study on Diet and Cancer.

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