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EFFECTS OF ULTRAVIOLET RADIATION

EFFECTS OF ULTRAVIOLET RADIATION. Henry W. Lim, MD Co-Chair National Council on Skin Cancer Prevention. PRESENTER. Chairman, Department of Dermatology, Henry Ford Hospital, Detroit, MI Photodermatology. DISCLOSURE.

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EFFECTS OF ULTRAVIOLET RADIATION

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  1. EFFECTS OF ULTRAVIOLET RADIATION Henry W. Lim, MD Co-Chair National Council on Skin Cancer Prevention

  2. PRESENTER • Chairman, Department of Dermatology, Henry Ford Hospital, Detroit, MI • Photodermatology

  3. DISCLOSURE • Consultant : La Roche-Posay/L’Oreal, Orfagen, Dow Pharmaceutical Sciences • Investigator: Johnson & Johnson

  4. ELECTROMAGNETIC RADIATION

  5. ULTRAVIOLET RADIATION UV λ (nm) Properties UVC 200-290 Germicidal UVB 290-320 Sunburn UVA 320-400 Pigment darkening, tanning

  6. EFFECTS OF UV • DNA damage • Erythema • Tanning • Vitamin D synthesis • Immunosuppression • Skin cancer

  7. EFFECTS OF UV • DNA damage

  8. UV AND DNA DAMAGE UVB: • Direct effect • Cyclobutane-pyrimidine dimers Bolognia, et al. Dermatology. 2008

  9. UV AND DNA DAMAGE(Agar NS, PNAS 4/04; 101:4954; Budiyanto A, P&P10/02; 76:397) UVA: • Indirect mechanism • Absorption by skin chromophores → reactive oxygen species → reacts with guanine → oxidative products (8-oxoG, 8-oxo-dG) • Mutagenic

  10. EFFECTS OF UV • DNA damage • Erythema

  11. ERYTHEMA • Primarily the effect of UVB • Peaks at 24 hrs

  12. EFFECTS OF UV • DNA damage • Erythema • Tanning

  13. MECHANISMS OF TANNING(Hönigsmann H, PPP 4/02; 18:75) • UV: activation of tyrosinase • UV  DNA damage  nucleotide fragments excised in repair  stimulate melanogenesis

  14. ERYTHEMA & TANNING • UVB: Erythema > tanning • UVA: Tanning > erythema • Tanning is an indication that DNA damage has occurred • There is no “safe tan”

  15. EFFECTS OF UV • DNA damage • Erythema • Tanning • Vitamin D synthesis • Action spectrum: UVB

  16. EFFECTS OF UV • DNA damage • Erythema • Tanning • Vitamin D synthesis • Immunosuppression • Skin cancer

  17. UV: IMMUNOSUPPRESSION AND SKIN CANCER(International Agency for Research on Cancer Working Group on artificial ultraviolet light and skin cancer. Green A, et al. Int J Cancer 3/07; 120:1116) • UV: immunosuppressive • Chronic UV exposure: • Photoaging changes • Squamous cell carcinoma • Basal cell carcinoma • Tanning bed users: • Melanoma • Squamous cell carcinoma

  18. NATURAL AND ARTIFICIAL UV • DNA damage, immunosuppression, skin cancer • WHO: UV is carcinogen • WHO: UV tanning beds: “carcinogenic to humans.” (El Ghissassi F, Lancet Oncol 7/09; 10: 751)

  19. NCSCP RECOMMENDATIONS • To reclassify sunlamps for tanning as Class II devices • To impose special controls: user labeling and user registry • To prohibit use by consumers younger than 18 years • To require license for facilities at which sunlamps may be used • To have training and certification of operators

  20. www.skincancerprevention.org

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