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Mapping Genes and Determining the Allele Frequency of Genotype Through the Loci of Independent Variables

Mapping Genes and Determining the Allele Frequency of Genotype Through the Loci of Independent Variables. Vanessa Grieco Dr. Lin Seminar October 6, 2003. CKR5 and Delta 32. CKR5 is a chemokine (chemical factor released by immune cell, acts as natural suppressor

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Mapping Genes and Determining the Allele Frequency of Genotype Through the Loci of Independent Variables

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  1. Mapping Genes and Determining the Allele Frequency of Genotype Through the Loci of Independent Variables Vanessa Grieco Dr. Lin Seminar October 6, 2003

  2. CKR5 and Delta 32 • CKR5 is a chemokine (chemical factor released by immune cell, acts as natural suppressor • CKR5 and receptor are proteins • If Delta 32 base pair deleted then a frame shift of amino acid occurs

  3. 32 magic number Addition or deletion not divisible by three will cause a frame shift. Codons are triplet code which consists of three nucleotides 33 has no frame shift

  4. Recessive versus Dominant • Recessive restriction is expressed with 2 copies • Dominate phenotype with only 1 allele • Allele is and alternative form of a gene • Homozygous (same alleles) • Heterozygous (different alleles)

  5. Mapping of CKR genes Dean et.al. 1996, Science, 273:1856-1862

  6. Genetic Markers and HIV-1 Infection Dean et.al. 1996, Science, 273:1856-1862, Fig.2

  7. Results • CKR5 was the only loci that displayed a significant distortion • No difference in allele frequencies of CKR5 between HIV-1-infected and HIV-1 antibody negative individuals • HIV negative individuals have recessive restriction • Heterozygous progresses disease later if it has one allele Delta 32

  8. Work Citied • Dean M. et.al.Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene. Science (Sept 27 1996) 273:1858-1862 • O'Brien Stephen J.and Dean M. The Search of AIDS-Resistance Gene. Scientific American, September, 1997  • http://www.projinf.org/fs/dp-CKR5_Fusin.html

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