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Swiss-Prot Brazil: Advancements in Protein Annotation for Pathogenic Microorganisms

Explore the cutting-edge annotation initiatives in Swiss-Prot Brazil focusing on virulence factors of pathogenic bacteria like Staphylococcus aureus, with insights into future perspectives on annotating proteins from protozoan pathogens. Collaborations with top experts in the field are driving innovative research.

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Swiss-Prot Brazil: Advancements in Protein Annotation for Pathogenic Microorganisms

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  1. Swiss-Prot Brasil: Estado da arte e perspectivas futuras Claudia B. Monteiro-Vitorello Swiss-Prot/LABINFO/LNCC

  2. National Laboratory of Scientific Computation (LNCC) • Ministry of Science and Technology (MCT) • The National Council for Scientific and Technological Development (CNPq) - foundation linked to MCT, to support Brazilian research. • Petrópolis, Rio de Janeiro

  3. Swiss-Prot + LNCC • Started August 1st, 2004 • 4 annotators: • Claudia B. Monteiro-Vitorello • Marisa Fabiana Nicolas • Luciane Prioli Ciapina • Luiz Fernando Zuleta

  4. The Human Proteomics Iniciative The Plant Proteome Annotation Project Toxin Annotation Project The HAMAP Project The Fungal Annotation Project Swiss-Prot Projects The Virus Annotation Project

  5. HAMAP Annotation of complete microbial proteomes in the Swiss-Prot Protein Knowledge Database High-quality Automated and Manual Annotation of Microbial Proteomes

  6. Swiss-Prot Brazil • Annotation of proteins involved in virulence/pathogenicity and host adaptation of pathogenic bacteria. • Staphylococcus aureus

  7. GLOBAL REGULATION OF Staphylococcus aureus VIRULENCE FACTORS sarH1 lytS-lytR lytS-lytR sar locus sar locus arlS-arlR arlS-arlR rot rot saeS-saeR mgrA mgrA P2 P3 P1 R S sarA sarC ? sarB RNA III sarR B D C A P3 Cell membrane P2 cna arg locus Antigens RNA III Collagen adhesin Enzymes fnbB Toxins sspC nuc fibronectin-binding protein Staphostatin B nuclease lip spa lipase protein A sspA, sspB hla, hld, hlg clfA,cflB Virulence factor genes hemolysin serine - cysteine protease clumping factor

  8. www.hamapbrazil.lncc.br

  9. annotators SIB, EBI Amos isb-sib.ch lncc.br CLAUDIA MARISA LUIZ LUCIANE LNCC

  10. http://br.expasy.org

  11. Perspectivas futuras: Anotação de proteínas de protozoários patogênicos: • Plasmodium falciparum • Leishmania • Trypanosoma • Theileria

  12. Tritryps Dra. Angela Cruz – USP/Riberão Preto Dr. Samuel Goldenberg – Instituto de Biologia Molecular do Paraná, FIOCRUZ. Theileria Dr. Trushar Shah - The International Livestock Research Institute (ILRI), Kenya. Swiss-Prot Anotação de proteinas de protozoários patogênicos

  13. http://www.labinfo.lncc.br

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