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Swiss-Prot Brasil: Estado da arte e perspectivas futuras Claudia B. Monteiro-Vitorello Swiss-Prot/LABINFO/LNCC

Swiss-Prot Brasil: Estado da arte e perspectivas futuras Claudia B. Monteiro-Vitorello Swiss-Prot/LABINFO/LNCC. National Laboratory of Scientific Computation (LNCC). Ministry of Science and Technology (MCT)

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Swiss-Prot Brasil: Estado da arte e perspectivas futuras Claudia B. Monteiro-Vitorello Swiss-Prot/LABINFO/LNCC

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  1. Swiss-Prot Brasil: Estado da arte e perspectivas futuras Claudia B. Monteiro-Vitorello Swiss-Prot/LABINFO/LNCC

  2. National Laboratory of Scientific Computation (LNCC) • Ministry of Science and Technology (MCT) • The National Council for Scientific and Technological Development (CNPq) - foundation linked to MCT, to support Brazilian research. • Petrópolis, Rio de Janeiro

  3. Swiss-Prot + LNCC • Started August 1st, 2004 • 4 annotators: • Claudia B. Monteiro-Vitorello • Marisa Fabiana Nicolas • Luciane Prioli Ciapina • Luiz Fernando Zuleta

  4. The Human Proteomics Iniciative The Plant Proteome Annotation Project Toxin Annotation Project The HAMAP Project The Fungal Annotation Project Swiss-Prot Projects The Virus Annotation Project

  5. HAMAP Annotation of complete microbial proteomes in the Swiss-Prot Protein Knowledge Database High-quality Automated and Manual Annotation of Microbial Proteomes

  6. Swiss-Prot Brazil • Annotation of proteins involved in virulence/pathogenicity and host adaptation of pathogenic bacteria. • Staphylococcus aureus

  7. GLOBAL REGULATION OF Staphylococcus aureus VIRULENCE FACTORS sarH1 lytS-lytR lytS-lytR sar locus sar locus arlS-arlR arlS-arlR rot rot saeS-saeR mgrA mgrA P2 P3 P1 R S sarA sarC ? sarB RNA III sarR B D C A P3 Cell membrane P2 cna arg locus Antigens RNA III Collagen adhesin Enzymes fnbB Toxins sspC nuc fibronectin-binding protein Staphostatin B nuclease lip spa lipase protein A sspA, sspB hla, hld, hlg clfA,cflB Virulence factor genes hemolysin serine - cysteine protease clumping factor

  8. www.hamapbrazil.lncc.br

  9. annotators SIB, EBI Amos isb-sib.ch lncc.br CLAUDIA MARISA LUIZ LUCIANE LNCC

  10. http://br.expasy.org

  11. Perspectivas futuras: Anotação de proteínas de protozoários patogênicos: • Plasmodium falciparum • Leishmania • Trypanosoma • Theileria

  12. Tritryps Dra. Angela Cruz – USP/Riberão Preto Dr. Samuel Goldenberg – Instituto de Biologia Molecular do Paraná, FIOCRUZ. Theileria Dr. Trushar Shah - The International Livestock Research Institute (ILRI), Kenya. Swiss-Prot Anotação de proteinas de protozoários patogênicos

  13. http://www.labinfo.lncc.br

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