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Immunology Essentials Introduction to Innate and Adaptive Immunity. Chapter 28. Cells of the Immune System. Two Circulatory System. Clicker Question: The primary lymphatic system is: lymph nodes brain. heart. bone marrow. toe nails. RBCs and WBCs. How to Recognize Non-Self from Self
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Immunology EssentialsIntroduction to Innate and Adaptive Immunity Chapter 28
Two Circulatory System • Clicker Question: The primary lymphatic system is: • lymph nodes • brain. • heart. • bone marrow. • toe nails.
How to Recognize Non-Self from Self Pathogen-Associated Molecular Patterns AND Pattern Recognition Receptors Innate Immunity: DESTROY !! and Present Antigen to Adaptive Immune Response
Adaptive Immune Responsse Antigen exposure stimulates cells for form clones of B and T cells. Clicker Question: Ag = Antigen
Ag Presentation to T-cells Clicker Question:
Adaptive Immunity: Specificity, Memory, and Tolerance. Clicker Question:
Adaptive Immunity: Specificity, Memory, and Tolerance. Clicker Question:
The Classic Cellular Response: Positive TB skin test. Clicker Question:
IgG Structure Antibodies bind Ag by the FAB portion = Fragment Antigen Binding. FC = Fragment-Constant region FAB FC
IgG Structure Clicker Question:
Antibody Production Against Protein Ags Clicker Question:
When Ag binds foreign Cell: Yummy ! Clicker Question:
Inflammation of a Child’s Foot • Inflammation Characteristics: • Redness (erythema) b. swelling (edema) • c. Pain. d. Heat.
Inflammation of a Child’s Foot • Inflammation can be caused by: • tissue injury. b. toxins. c. Ab-Ag complexes • Brought about by release of cytokines capillary swelling + permeability
Local vs System Inflammation Systemic Inflammation: Septic Shock or Anaphylatic Shock
Vaccines • Killed whole cell vaccines or inactivated whole virus vaccines. • Partially purified cell fractions: tuberculin (purified Mycobacterium tuberculosis cell wall. • Mixtures of pure polysaccharides. Pneumovax-23. • Synthetic peptides. Minimum size of protein to get an immune response = 100 aa’s long. Antigenic determinants are ~20 aa’s long. Therefore carrier proteins are needed. First done: Foot and Mouth disease in cattle. • DNA vaccines.
Clonal Selection Clicker Question: