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Immunology Essentials Introduction to Innate and Adaptive Immunity

Immunology Essentials Introduction to Innate and Adaptive Immunity. Chapter 28. Cells of the Immune System. Two Circulatory System. Clicker Question: The primary lymphatic system is: lymph nodes brain. heart. bone marrow. toe nails. RBCs and WBCs. How to Recognize Non-Self from Self

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Immunology Essentials Introduction to Innate and Adaptive Immunity

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  1. Immunology EssentialsIntroduction to Innate and Adaptive Immunity Chapter 28

  2. Cells of the Immune System

  3. Two Circulatory System • Clicker Question: The primary lymphatic system is: • lymph nodes • brain. • heart. • bone marrow. • toe nails.

  4. RBCs and WBCs

  5. How to Recognize Non-Self from Self Pathogen-Associated Molecular Patterns AND Pattern Recognition Receptors Innate Immunity: DESTROY !! and Present Antigen to Adaptive Immune Response

  6. Adaptive Immune Responsse Antigen exposure stimulates cells for form clones of B and T cells. Clicker Question: Ag = Antigen

  7. Ag Presentation to T-cells

  8. Ag Presentation to T-cells Clicker Question:

  9. Adaptive Immunity: Specificity, Memory, and Tolerance. Clicker Question:

  10. Adaptive Immunity: Specificity, Memory, and Tolerance. Clicker Question:

  11. The Classic Cellular Response: Positive TB skin test. Clicker Question:

  12. Clicker Question:

  13. Clicker Question:

  14. IgG Structure Antibodies bind Ag by the FAB portion = Fragment Antigen Binding. FC = Fragment-Constant region FAB FC

  15. IgG Structure Clicker Question:

  16. Antibody Production Against Protein Ags Clicker Question:

  17. When Ag binds foreign Cell: Yummy ! Clicker Question:

  18. Abs can also bind Soluble Foreign Molecules

  19. Inflammation of a Child’s Foot • Inflammation Characteristics: • Redness (erythema) b. swelling (edema) • c. Pain. d. Heat.

  20. Inflammation of a Child’s Foot • Inflammation can be caused by: • tissue injury. b. toxins. c. Ab-Ag complexes • Brought about by release of cytokines  capillary swelling + permeability

  21. Local vs System Inflammation Systemic Inflammation: Septic Shock or Anaphylatic Shock

  22. Immunoglobin Illustration from 9th Ed

  23. Importance of Natural Immunity

  24. Active and Passive Immunity

  25. HIV infection

  26. Vaccines

  27. Childhood Vaccination Schedule

  28. Vaccines • Killed whole cell vaccines or inactivated whole virus vaccines. • Partially purified cell fractions: tuberculin (purified Mycobacterium tuberculosis cell wall. • Mixtures of pure polysaccharides. Pneumovax-23. • Synthetic peptides. Minimum size of protein to get an immune response = 100 aa’s long. Antigenic determinants are ~20 aa’s long. Therefore carrier proteins are needed. First done: Foot and Mouth disease in cattle. • DNA vaccines.

  29. Hypersensitivities

  30. Immediate Hypersensitivities:Allergies

  31. Type 4 Delayed Type Hypersensitivity: Poison Ivy

  32. Type 4 - Delayed Type HypersensitivityThe TB Skin Test

  33. Autoimmune Diseases

  34. Superantigens Mediate Pathological Inflammation

  35. Clonal Selection Clicker Question:

  36. T-Cell Clonal Selection

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