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Bacterial Genetics. Heredity and variation. heredity variation genotype variation phenotype variation. Variation. morphology and structure virulence resistance colony 光滑型菌落( smooth , S ) 粗糙型菌落 ( rough , R ). genetic materials. chromosome plasmid bacteriophage , phage
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Heredity and variation • heredity • variation genotype variation phenotype variation
Variation • morphology and structure • virulence • resistance • colony 光滑型菌落(smooth,S) 粗糙型菌落(rough,R)
genetic materials • chromosome • plasmid • bacteriophage,phage • transposon,Tn
Classification of plasmid • 根据细菌的接合作用 (conjugative ,nonconjugative) • 根据质粒的不相容性 (incompatibility) • 根据编码的生物学性状 (fertility,resistance,virulence)
mechanism of bacterial variation • mutation • gene transfer and recombination
mutation • spontaneous mutation • wild strain • wild type • mutant strain • mutation types • reverse mutation) • suppressor mutation)
Transfer and recombination of gene • transformation • conjugation • transduction • generalized • Restricted • lysogenic conversion • protoplast fusion
Application • Diagnosis,prevention and treatment • Detection of tumor • Epidimiology • Molecular biology • Engineering