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The Effect of Caffeine on Neurological Dopamine Production

The Effect of Caffeine on Neurological Dopamine Production. Process Dynamics & Control October 13 th , 2004 Student Name 1 Student Name 2. Presentation Outline. Introduction Simulation Assumptions Process Outcomes Laplace via Maple Matlab Simulink Conclusion. What is Caffeine?.

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The Effect of Caffeine on Neurological Dopamine Production

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  1. The Effect of Caffeine on Neurological Dopamine Production Process Dynamics & Control October 13th, 2004 Student Name 1 Student Name 2

  2. Presentation Outline • Introduction • Simulation Assumptions • Process • Outcomes • Laplace via Maple • Matlab • Simulink • Conclusion

  3. What is Caffeine? • The most commonly used neurological drug worldwide • trimethylxanthine, (C8H10N4O2) • bitter tasting white powder Retrieved from: www.cs.virginia.edu/.../ caffeine-molecule.gif

  4. Common Substances • Coffee, tea, soft drinks, and pain medication • Caffeine Content: • Brewed coffee: 40-180 mg • Black Tea: 20-100 mg • Excedrin: 65 mg • Mountain Dew: 55 mg • Green Tea: 8-36 mg

  5. What is Dopamine? • Neurotransmitter • Movement • Thought processes • Emotions • Pleasure “Rewards” centers of the brain Retrieved from: http://www.bip.bham.ac.uk/osmart/msctox/

  6. The Relationship Between Caffeine and Dopamine • Caffeine has ½ life of ~6 hours in a healthy person • Enters Digestive tract • Some caffeine is lost in liver • Remainder enters bloodstream • Caffeine enters the brain • Stimulates excessive dopamine release • Blocks uptake receptors

  7. Ultimate Response:

  8. Simulation Assumptions • Body consists of 3 tanks • Stomach, Liver, and Brain • Flow rates, tank volumes and density remain constant • Dopamine production is a first order chemical reaction • Caffeine→Dopamine

  9. Initial Conditions

  10. Ci,caf., F1 F5,D5 F2, C1 F4, C4, D4 Stomach: C1, Vs Liver: D2, C2, Vl Brain: D5, C5, Vb Caffeine Dopamine rb=k1C5 C3, F3, D3 Simulation Process

  11. Focus • Amount of Dopamine produced as a function of input Caffeine

  12. Mass Balances: Stomach Equation 1. Stomach Mass Balance (Caffeine) Ci,caf., F1 F2, C1 Stomach: C1, Vs

  13. Mass Balance: Liver F5,D5 Equation 2. Liver Mass Balance (Caffeine) F2, C1 F4, C4, D4 Liver: D2, C2, Vl Equation 3. Liver Mass Balance (Dopamine) C3, F3, D3

  14. Mass Balance: Brain F5,D5 Equation 4. Brain Mass Balance (Caffeine) F4, C4, D4 Equation 5. Brain Mass Balance (Dopamine) Brain: D5, C5, Vb Caffeine Dopamine rb=k1C5

  15. Laplace Transform: Steady State S-Domain t-Domain =Ci,caf{ }

  16. Caffeine Impulse Function

  17. Caffeine Unit Step Function

  18. Caffeine at Steady-State

  19. Dopamine at Steady State

  20. Dopamine Unit Step Function

  21. Dopamine Impulse Function

  22. Simulink Unit Step Function For Caffeine

  23. Simulink Unit Step Function For Dopamine

  24. Simulink Impulse Function for Caffeine

  25. Simulink Impulse Function for Dopamine

  26. Conclusion • Achieved anticipated results in the theoretical process • Possible differences in real process • Suggestions • Thanks to Dr. Rodgers

  27. Questions?

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