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Authors Asst. Dr. Sirikul Chunsawang Collage of Engineering, Rangsit University, THAILAND.

Title : Capsule Production from Chitosan. Authors Asst. Dr. Sirikul Chunsawang Collage of Engineering, Rangsit University, THAILAND. Asst. Dr. Sirirat Wongprakornkul Faculty of Science, Khon Kaen University, THAILAND. Introduction. Chitosan is derived from chitin by removing

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Authors Asst. Dr. Sirikul Chunsawang Collage of Engineering, Rangsit University, THAILAND.

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  1. Title : Capsule Production from Chitosan Authors Asst. Dr. Sirikul Chunsawang Collage of Engineering, Rangsit University, THAILAND. Asst. Dr. Sirirat Wongprakornkul Faculty of Science, Khon Kaen University, THAILAND.

  2. Introduction Chitosan is derived from chitin by removing and refining the acetyls through a process called deacetylation. unsaturated amino polysaccharide similar to cellulose which is plants fiber

  3. Objectives 1. To prepare chitosan from prawn shells 2. To prepare chitosan capsule 3. To compare chitosan capsule with gelatin capsule

  4. Methodology 1. preparation of chitin 2. preparation of chitosan 3. capsule production from chitosan 4. testing of chitosan and gelatin capsule properties.

  5. prawn shells 8%w NaOH 1:6 w/v 80-90 ๐C 2-3 h reduced protein 8%w HCl 1:6 w/v25-30๐C24h reduced mineral 1. preparation of chitin 150g 300m – 1.18mm 250g 1.18mm - 2.36mm 300g 2.36mm – 4.75mm

  6. chitin 50%w NaOH 1:10w/v 90-120๐C4-5h deacetylation Compared with std Sigma –Aldrich 2. preparation of chitosan

  7. 3. capsule production from chitosan Chitosan 0.1M acetic acid 0.1:5w/v Viscous solution capsule Thai Industrial Standards of solid gelatin capsule, (TIS 913-2532)

  8. 4. testing of chitosan and gelatin capsule properties. • Thai Industrial Standards of solid gelatin capsule, • (TIS 913-2532) • size and size error of capsule • moisture resistance • dissociation • moisture content • ash content.

  9. Results & Discussion chitin chitosan The color of chitosan is white & transparent, crisp flake %yield= 24-30

  10. NH2 Amide C – O COC Tranmittance of standard chitosan from Sigma Aldrich

  11. NH2 Amide C – O COC Transmittance ofchitosan COC

  12. Ash content of chitosan Ash content of standard chitosan from Sigma Aldrich equal to o.5%

  13. (left) Gelatin capsule (right) Chitosan capsule

  14. size of gelatin capsule

  15. size of chitosan capsule

  16. Result of size and size errorof capsule For statistical analysis, the t-test was raised to perform. We found that both chitosan capsule and gelatin capsule are not significant. • One side of capsule with p-value = 0.799 • Other side of capsule with p-value = 0.644 • closed capsule with p-value = 0.799 Mass of chitosan capsule is lighter than gelatin capsule.

  17. Result of moisture resistance Chitosan capsule is more durable than gelatin capsule when we kept into water at 25๐c for 15 min.

  18. Result of dissociation of capsule Both gelatin and chitosan capsules were kept into water pH 7 at 372 ๐C and detected time when they were dissociated retesting again by kept into acetic acid at difference concentration: pH 2, 3, 4, 5, and 6 respectively.

  19. Result of moisture content gelatin and chitosan capsule had average moisture contents 15.138% and 19.703% Result of ash content of capsule ash content of gelatin capsule 1.302% ash content of chitosan capsule 1.123%

  20. Conclusion • 150 g of 300 m - 1.18 mm produce 36 g of chitosan • 250 g of 1.18 mm - 2.36 mm produce 60 g of chitosan • 300 g of 2.36 mm.- 4.75 mm produce 72 g of chitosan (24-30%yield) • Chitosan capsule is resistance to moisture and • dissociate in pH 2 to 3 solution which is the • suitable pH in stomach.

  21. Acknowledgement Kingfisher holding Ltd. Rangsit University

  22. Thank you for your attention.

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