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Neuro-Psychiatric Comorbidity among Psoriatic Adolescents

Neuro-Psychiatric Comorbidity among Psoriatic Adolescents. Eran Galili , Aviv Barzilai , Rony Shreberk -Hassidim, Ilan Merdler , Tomm Caspi , Nadav Astman Journal reference: 10.1111/bjd.16031. Introduction What’s already known?.

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Neuro-Psychiatric Comorbidity among Psoriatic Adolescents

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  1. Neuro-Psychiatric Comorbidity among Psoriatic Adolescents EranGalili, Aviv Barzilai, RonyShreberk-Hassidim, IlanMerdler, TommCaspi, NadavAstman Journal reference: 10.1111/bjd.16031

  2. Introduction What’s already known? • Adultpsoriasis is a risk factor for psychiatric and neurological diseases • Few studies among children, comprising of subjects of mixed age groups (younger than 18 years), have linked psoriasis to anxiety, depression and social disabilities

  3. Methods • Design: A population based cross-sectional study • Database: Army recruits’ medical records • Inclusion criteria: Age 16 to 18 years • Comparisons were made by multivariate analysis adjusted for: • Age, Gender, Country of origin, BMI, Socio-economic status and IQ score • Psoriasis severity definition: • Mild: with limited skin involvement, using topical treatment only • Moderate to severe: with extensive skin area involvement, or treated with phototherapy or systemic therapy

  4. Methods: Assessed Comorbidity CNS, central nervous system; *Consists of: multiple sclerosis, neurodegenerative disease and cerebrovascular accident

  5. Results: Characteristics of study participants * On a scale of 1 (lowest) to 10 (highest)

  6. Results: Comparison of neuro-psychiatric comorbidity between psoriatic and healthy adolescents NS, non-significant; ᵃ Calculated for a subgroup of patients (Psoriasis N=1135, Controls N=265023); **pvalue < 0.01, ***pvalue < 0.001

  7. Results: Influence of psoriasis severity compared to controls ᵃ Calculated for a subgroup of patients (Mild psoriasis N=669, moderate to severe psoriasis N=466 and controls N=265023), univariate analysis; **p value< 0.01, ***p value< 0.001

  8. Discussion What does this study add? • Adolescent psoriasis was found to be associated with migraine and non-migraine headaches, as well as psychological symptoms, including anxiety and impaired social adjustment skills • Neuro-Psychiatric comorbidity was found to be related only to moderate to severe psoriasis

  9. Conclusions • Clinicians should be aware of the collateral impact of psoriasis, especially upon adolescents with moderate to severe disease

  10. Call for correspondence • Why not join the debate on this article through our correspondence section? • Rapid responses should not exceed 350 words, four references and one figure • Further details can be found here: (insert link to author instructions)

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