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Tissue Engineering of the Heart

Tissue Engineering of the Heart. Melissa Andrews. What is Tissue Engineering?. Combines cells, engineering, biology, and medicine Repairs or replaces part of or whole tissues It will likely revolutionize the world. Scaffolds. Provides temporary support Purposes:

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Tissue Engineering of the Heart

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  1. Tissue Engineering of the Heart Melissa Andrews

  2. What is Tissue Engineering? • Combines cells, engineering, biology, and medicine • Repairs or replaces part of or whole tissues • It will likely revolutionize the world

  3. Scaffolds • Provides temporary support • Purposes: • Allows cells to attach and then transfer • Allows for the vital cell nutrients to diffuse • Make use of some mechanical and biological influences

  4. Scaffolds • Important both in vitro and ex vitro • Needs to be biodegradable and flexible especially for a heart • Picture  used specifically for heart repair

  5. Process • Autologous cells are obtained and placed into the bioreactor • Scaffold is then covered with the new cells • The scaffold is then transplanted into the body

  6. Ratner • Ratner, a UW professor of bioengineering • Ratner built a new and different scaffold that will be injected the heart. • The scaffold supports and regulates the muscle growth. • In the future, the procedure would be done before scar tissue forms.

  7. Ratner • Many more heart scaffold and tissue patches are being developed. • Others can involve different types of cells along with the cardiac muscles and are much more expensive. • He found that it took 4 weeks for the scaffold to degrade.

  8. Implanting • Heart cells in a culture dish do not have a blood supply. • Therefore getting blood to those cells immediately is essential. • Size of scaffold implanted – 1/3 of a mm wide by 4 mm long

  9. Limitations • Large variations in tissues • Ability of newly generated tissue

  10. Resources • "Scaffolding for Heart Stem Cells after a Heart Attack." The Daily Heart Beat — Reliable Information and Commentary by a Doctor/Heart Attack Survivor. Web. 7Nov. 2011. <http://heartcurrents.com/scaffolding-heart-stem-cells-heart-attack/>. • Tissue Engineering and Wound Healing: An Overview: History of Tissue Engineering. Health Management Publications, Inc., 2007. Web. 2011. • 3. Davis, Ph.D., Kevin. "Advances in Cardiac Tissue Engineering and Cardiac Tissue Replacement Modalitie." Tissue Engineering. By Scott Seidman. 2002. Web. 8 Nov. 2011. • <http://sa.rochester.edu/jur/issues/fall2003/krebs.pdf>. • "Heart Transplants: Statistics." American Heart Association. Web. 18 Feb. 2011. <http://www.americanheart.org/presenter.jhtml?identifier=4588>. • 5. "NIH Definition of Tissue Engineering/Regenerative Medicine." Tissue-Engineering. Web. 8 Nov. 2011. <http://www.tissue-engineering.net/index.php?seite=whatiste>

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