Lab This Week: EKGs and Blood Pressure

1. Lab This Week: EKGs and Blood Pressure • Bring textbook • Bring calculator • Wear clothes and shoes for running stairs • Easy access to wrist and ankles for ECG electrodes • Easy access to arms for Blood Pressure measurement • Wear Wofford logo if you wanna be in Olencki pics

2. Revising Abstracts Instructions forthcoming. Due date to be announced. Keep all papers together for resubmission!

3. For Friday Quiz • Be prepared to draw and label electrocardiograms for • Normal • 1st degree heart block • 2nd degree heart block • Be able to diagnose from an ECG • Atrial fibrillation • Ventricular fibrillation • Premature ventricular systole • 3rd degree heart block

4. 1QQ#26 for 10:30 • Catecholamines acting on beta-adrenergic receptors cause arteriolar smooth muscles to relax. • Vasopressin is a vasoconstrictor. • Of the several modes of exchange in capillaries, diffusion is the most important for the delivery of nutrients and removal of wastes. • There are five Starling forces. • For bulk flow, water and colloids move through aqueous channels and intracellular clefts. e) Was not graded. I intended the term to be intercellular clefts and I didn’t do a good job of making a distinction.

5. 1QQ#26 for 11:30 • Catecholamines acting on alpha-adrenergic receptors cause arteriolar smooth muscles to relax. • Endothelin-1 is a vasoconstrictor. • Of the several modes of exchange in capillaries, bulk flow is the most important for the delivery of nutrients and removal of wastes. • There are only three Starling forces. • During bulk flow in capillaries, water and crystalloids move through aqueous channels and intracellular clefts. e) Was not graded. I intended the term to be intercellular clefts and I didn’t do a good job of making a distinction.

6. Bulk Flow through aqueous channels and intracellular clefts S 10 Figure 12.42 Starling Forces Regulated by arterioles Net filtration = 4L/day Main difference in the Pulmonary circuit?

7. Bulk Flow and Starling Forces

8. S 12 Who Cares? Aunt Esther Cancer of the liver; Failure of hepatocytes to produce plasma colloids

9. Aunt Ester Pc ∏c

10. ∏c Pc Hypotension Actions of Histamine and antihistamines

11. S 11 Fig. 12.43 Pc Pc Pc

12. S 1 Figure 12.47 Fate of 4 L/d excess filtrate Liver & Bone Marrow& Spleen Mode of propulsion?

13. Filariasis in Haiti: Washington Post Article

14. S 2 Figure 12.44 Veins areCapacitance vessels(high compliance)with valves for unidirectional flow Arteries are low compliance, so any increase in volume increases pressure.

15. S 3 Fig. 12.53 MAP = CO x TPR Negative feedback control:stimulus, receptors, afferent pathway(s), integrator, efferent pathway(s), effector(s)response(s)

16. S 4 Fig. 12.54 What happens to the set point for MAP during exercise?

17. Story Time S 5 A Neuroscientist in New Orleans

18. S 2 MAP = CO x TPR MAP = (HR x SV) x TPR Mean Arterial Pressure = Cardiac Output x Total Peripheral Resistance Loss of 1 liter of blood from vein → ↓ blood volume → ↓ MAP → ….. Creating your Hemorrhage Diagram

19. Beginning with a loss of about 1 liter of blood from a vein, diagram the early events associated with hemorrhage and the negative feedback responses to hemorrhage in a well-organized diagram. Write legibly! Completeness, accuracy, and detail, together with the proper sequence earn maximal points. The following abbreviations can be used: AI, AII, JGA, mAChR, Hct, Q, SV, EF, RBC, HR, EDV, ACh, ANH, ADH, CO, TPR, EPO, VR, MAP, EPI, NE, SAN, aAdR , bAdR, Symp (sympathetic), Parasymp (parasympathetic), PV, r (radius), Pc, fAP (frequency of action potentials.) Any other abbreviations must be defined. "If in doubt, write it out!" Use single headed arrows (→) to indicate sequential relationships and doubled-stemmed arrows to indicate increases or decreases.