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mRNP Transport through the Nuclear Pore Complex (NPC)

mRNP Transport through the Nuclear Pore Complex (NPC).

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mRNP Transport through the Nuclear Pore Complex (NPC)

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  1. mRNP Transport through the Nuclear Pore Complex (NPC)

  2. The NPC consists of FG (phenylalanine-glycine)-repeat containing nucleoporins (FG Nups), as well as other nuclear and non-nuclear proteins including at least two nucleoporins, Nup153 and Nup358 containing zinc-finger domains and Ran-binding domains. mRNA is associated with the Mex67/Tap and Mtr2/p15 heterodimer (also known as the general mRNA export receptor) for transport from the nucleus. Mex67/Tap is characterized by the presence of LRR (Leucine-Rich Repeat), M (Middle-) and C (C-terminal-) domains. It is this heterodimer that binds directly to the FG-Nups lining the NPC and providing transient docking sites as the mRNP traverses the nuclear basket and is released from the cytoplasmic fibrils. Adapted from Reed R. et al, cell 108:523, 2002. mRNP Transport through the Nuclear Pore Complex (NPC)

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