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Organization of the NPC

Organization of the NPC. Specificity Models of the NPC. Brownian Gate. Selective Phase. ‘Oily Spaghetti. Week 2: RNA maturation transport, & localization. RNA processing: brief overview. RNA export to the cytoplasm: model systems. RNA degradation.

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Organization of the NPC

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  1. Organization of the NPC

  2. Specificity Models of the NPC Brownian Gate Selective Phase ‘Oily Spaghetti

  3. Week 2: RNA maturation transport, & localization RNA processing: brief overview RNA export to the cytoplasm: model systems RNA degradation Links between RNA processing, transport, degradation RNA localization in the cytoplasm

  4. mRNA transport Evidence for checkpoints?

  5. Specific process for Pol II transcripts nuclear CBC binds to m7G-cap: role in splicing, transport, stability (exchanged in cytoplasm) Function in transport, stability, translation

  6. CPSF: cleavage and polyadenylation specificity factor CStF: cleavage stimulatory factor CF: cleavage factor PAP: polyA polymerase PAB: polyA binding protein Function in transport, stability, translation

  7. Compartments inside the nucleus 1. Nucleolus

  8. 2. Perichromatin granule clusters Carter et al., Science (1993) 259: 1330

  9. Balbiani Rings (Chironomus tentans)

  10. SUMMARY I. Multiple steps of mRNA biosynthesis are tightly coupled II. Mex67/TAP is one major mRNA export factor Binding to mRNA may already occur at the site of transcription III. Many questions remain - How are mRNA substrates released in the cytoplasm? - Are there multiple mRNA export pathways? - How is processing and transport coupled? etc.

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