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Supplemetal Fig. 1

LKB1. -. +. pAMPK(T172). HA-AMPK. FLAG-LKB1. LKB1. -. +. pAMPK(T172). AMPK. pACC(S79). FLAG-LKB1. Supplemetal Fig. 1. B. A. C. LKB1iSP. -. +. -. -. +. -. GFPRNAi. -. -. +. -. -. +. 2DG (20 mM). -. -. -. +. +. +. pAMPK(T172). AMPK. LKB1. Supplemetal Fig. 2.

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Supplemetal Fig. 1

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  1. LKB1 - + pAMPK(T172) HA-AMPK FLAG-LKB1 LKB1 - + pAMPK(T172) AMPK pACC(S79) FLAG-LKB1 Supplemetal Fig. 1 B A C LKB1iSP - + - - + - GFPRNAi - - + - - + 2DG (20 mM) - - - + + + pAMPK(T172) AMPK LKB1

  2. Supplemetal Fig. 2 A LKB1 -D194A LKB1 -WT AMPKi (M) - - - autorad FLAG-LKB1 B AMPKi (M) - + - + - - + + LKB1 autorad FLAG-LKB1 C AMPK-DN AMPK-WT AMPKi (M) - - autorad Coomassie/ TSC2 fragment HA-AMPK

  3. Supplemetal Fig. 3 A LKB1 - + Rapamycin (nM) 0 20 40 pS6K(T389) pS6K(T389) S6K S6K HA-LKB1 B LKB1 - - + + - - + + - + + + Rheb - WT - WT - L64 - L64 - - WT 5A pS6K1(T389) HA-S6K FLAG-LKB1 Myc-Rheb

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