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Why Sheep Are a Good Model

Why Sheep Are a Good Model. Early play and social behaviors differ between sexes Juvenile/adult social behaviors differ between sexes Reproductive behaviors differ between sexes. Sheep Critical Period. Postnatal 1. timing of pubertal increase in GnRH secretion function of GnRH

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Why Sheep Are a Good Model

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  1. Why Sheep Are a Good Model • Early play and social behaviors differ between sexes • Juvenile/adult social behaviors differ between sexes • Reproductive behaviors differ between sexes

  2. Sheep Critical Period Postnatal 1. timing of pubertal increase in GnRH secretion function of GnRH surge system MASCULINIZATION DEFEMINIZATION conception birth STEROIDS ORGANIZE FEEDBACK CONTROL OF GnRH SECRETION 0 30 60 90 120 150 days of pregnancy

  3. Treatment • Pregnant females injected with testosterone or oil vehicle during 2nd trimester from 30-90 days of gestation • Groups: • 30-90 days of oil [CM and CF] • 30-90 days of TP (100 mg 2x/week) [TM and TF] • 60-90 days of TP (100 mg 2x/week) [F only]

  4. Physiological Consequences • TP at both durations causes fetal growth retardation in both sexes (weight, height and chest circumference) Mannikam, et al, Endocrinology, 2004 • TP for 30-90, but not 60-90 days, alters external genitalia in both sexes • TP at both durations causes male urination pattern in females

  5. Growth Curves

  6. Testosterone Levels

  7. External Genitalia Mannikam, et al, Endocrinology, 2004

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