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HOW CAN WE MAKE THE GOLDEN YEARS MORE GOLDEN?. Kirk Panneton, M.D., FACP George Giokas, M.D. Medical Director, Senior Services Director, Palliative Care CDPHP The Community Hospice
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HOW CAN WE MAKE THE GOLDEN YEARS MORE GOLDEN? Kirk Panneton, M.D., FACP George Giokas, M.D. Medical Director, Senior Services Director, Palliative Care CDPHP The Community Hospice September 8, 2012
Goals of presentation • Discuss the aging process…can it be altered? • Define the Metabolic Syndrome • Review the effects of polypharmacy • Propose tips on being more successful with Geriatric care
AGING • Cell proliferation • Chromosomal changes • Key trigger • usually occurs in late teens/early twenties
GENETICS • Certain genes seem to lead to longevity • certain populations that live longer • Sir 2 gene • one of a family of genes (sirtuins) • present in all complex forms of life • If eliminated, life span decreases by 30 – 40 % • If stimulated, certain proteins get activated which help protect cellular mechanisms
OTHER THEORIES • Metabolic rate (Olshansky) • Oxidation of free radicals (Sinclair) • Chromosomal mutations (Kunkel) • Caloric restriction (CR) appears to be at the center of all of these studies; plant and animal models all show healthier longevity when under the stress of CR.
METABOLIC SYNDROME(SYNDROME X OR INSULIN RESISTANCE SYNDROME) • Characteristics: • Central obesity • Insulin resistance • Risk factors: • Aging • Genetics • Hormonal changes • Decreased exercise
PHYSICAL FINDINGS • BP > 130/85 • FBS > 100 • Waist measurement • Men > 40 • Women > 35 • HDL • Men < 40 • Women < 50 • Triglycerides > 150
TREATMENT • Weight loss ( 7 – 10% ) • Exercise ( 5 – 7 days/week ) • Nutritional counseling • Low dose ASA • No smoking
WAYS TO AGE MORE EFFECTIVELY • Less calories • More activity • Physical • Mental • Meet psychosocial needs • Community resources • Less dependence on medications
POLYPHARMACY • > 5 Medications • ADR’s – adverse drug reactions • Responsible for up to 1/3 of all hospital admissions in the elderly • Functional decline • Lethargy • Decreased appetite/weight loss • Change in bowel function • Gait/mobility • depression
Thanks to Faddy Morgan and Ryan Watson Albany College of Pharmacy and Health Sciences Pharm. D. Candidate 2011 • 20% of elders in the community • take more than • 10 meds per day!!
79 y.o. with COPD, DM, HBP, DJD, osteoporosis • If the relevant practice guidelines followed… • 12 meds ($406 a month) • CM Boyd, et al Clinical Practice Guidelines and Quality of Care for Older • Patients With Multiple Comorbid Diseases. JAMA. 2005;294:716-724.
CASE EXAMPLE • 88 y.o. female….living independently in a flat above her daughter’s family. No meds. PMH significant for memory loss and some weight loss. • Falls and sustains an acute vetebral fracture….brought to the emergency room • W/U: mid back pain…ambulates with assistance…no other significant findings except osteopenia on x-rays • Tx: Lortab 5mg. every 4 hrs. Fosamax 10mg tabs one a day
GERIATRIC CARE TIPS • Limit medications • Easy dosing • Use generics ( be aware of costs! ) • Beware of certain drug classes ( Beer’s list ) • Review for side effects • Brown bag analysis • D/C meds after therapeutic effect realized • Encourage exercise • Physical • Mental
TIPS (CON’T) • Encourage work and/or volunteer activity • Encourage social interaction • Remember caregiver support • Respite • Knowledge of community resources • Advance directives • For frail elders, review goals in care and goals in life