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NATURALEZA DEL EEG

NATURALEZA DEL EEG. *NEURONA PIRAMIDALES. *FLUJO - - POTENCIAL POSTSINAPTICO EXCITADOR (PPSE). *LEY DE OHM - - (V = I*R). R m > > R e V m > V e. EEG HUMANO NORMAL. FRECUENCIAS:. a (8 - 13 H z ). b (13 - 30 H z ). d (0.5 – 4 Hz). q (4 - 7 H z ). EEG EPILEPTICO.

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NATURALEZA DEL EEG

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  1. NATURALEZA DEL EEG *NEURONA PIRAMIDALES *FLUJO - - POTENCIAL POSTSINAPTICO EXCITADOR (PPSE) *LEY DE OHM - - (V = I*R) • Rm > > Re • Vm > Ve

  2. EEG HUMANO NORMAL FRECUENCIAS: a (8 - 13 Hz) b (13 - 30 Hz) d (0.5 – 4 Hz) q (4 - 7 Hz)

  3. EEG EPILEPTICO

  4. DESPLAZAMIENTO DESPOLARIZANTE PAROXISTICO (DDP)

  5. CRISIS PARCIAL PERIODO INTERICTAL SIMPLE SINCRO. NEURONAL FASES: COMPLEJA TIPOS : PROPAGACION GENERALIZACION GENERALIZADA 2aria

  6. EXCITADORES E INHIBIDORES EXCITADORES: Activación de canales excitadores mediados por glutamato como los canales-receptores: - AMPA (a-amino-3-hidroxi-5-metilisoxazol-4-propionato). - NMDA (N-metil-D-aspartato). - Canales de Ca2+ sensibles al voltaje. INHIBIDORES: Se genera fundamentalmente por: - canales de K+ dependientes de Ca2+ y del voltaje. - conductancias al cloruro (GABAA). - conductancias al K+ (GABAB).

  7. PERIODO INTERICTAL *ACTIVIDAD ANORMAL : FOCO EPILEPTOGENO *HAY POSHIPERPOLARIZACION

  8. DESARROLLO CRISIS *POSHIPERPOLARIZACION NO EXISTE *PROPAGACION FUERA DEL FOCO *FRACASA LA REPOLARIZAION *SALVA DE POTENCIALES CONTINUA

  9. MODELO DE CIRCUITO

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