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Spectroscopic SWIFT Djaudat Idiyatullin , Curt Corum,

Spectroscopic SWIFT Djaudat Idiyatullin , Curt Corum, Steen Moeller, Jutta Ellermann, Michael Garwood Center for Magnetic Resonance Research (CMRR), Department of Radiology University of Minnesota Medical School, Minneapolis, Minnesota, USA.

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Spectroscopic SWIFT Djaudat Idiyatullin , Curt Corum,

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  1. Spectroscopic SWIFT Djaudat Idiyatullin, Curt Corum, Steen Moeller, Jutta Ellermann, Michael Garwood Center for Magnetic Resonance Research (CMRR), Department of Radiology University of Minnesota Medical School,Minneapolis, Minnesota, USA

  2. Declaration of Conflict of Interest or Relationship Speaker Name: Idiyatullin Djaudat I have no conflicts of interest to disclose with regard to the subject matter of this presentation.

  3. 1 Goal of project FM G • Spectroscopic imaging based on SWIFT with sensitivity to broad T2 distribution including T2 in microsecond time scale. acq SWIFT (SWeep Imaging with Fourier Transformation) Projection method FM pulses for the excitation Acquisition in gaps between pulse elements Sensitive to short T2

  4. Spectroscopic projection imaging Lauterbur, Levin and Marr, 1984 “Theory and Simulation of NMR Spectroscopic Imaging and Field Plotting by Projection Reconstruction Involving an Intrinsic Frequency Dimension”

  5. θ, degree Spectroscopic SWIFT 2D spatial +1D spectroscopic (hemisphere)

  6. τp dw Spectroscopic SWIFT … …

  7. oil X water Y Ω Spectroscopic SWIFT- first experience Vegetable oil + water, 2D spatial + 1D spectral The total number of projections was 7748, FOV = 5 cm2, bw,max = 125 kHz, Ω = 3 kHz, matrix = 903, Acq time = 6 min

  8. 2D spatial + 1D spectral Four tubes with different concentration of iron-oxide (-Fe2O3) nanoparticles in agar 0.0086 nM/L 4.3 nM/L 0.086 nM/L 0.86 nM/L The total number of projections was 7748, FOV = 3 cm, matrix = 903, bw,max = 125 kHz, Ω = 18 kHz, Acq time = 65 sec

  9. T2 = 0.075ms 4.3 nM/L T2 = 2.5ms 0.0086 nM/L T2 = 0.2ms 0.86 nM/L T2 = 1.5ms 0.086 nM/L 2D spatial + 1D spectral Four tubes with different concentration of iron-oxide (-Fe2O3) nanoparticles in agar

  10. PD T2 B0 3D spatial + 1D spectral Four tubes with different concentration of iron-oxide (-Fe2O3) nanoparticles in agar Integral Max/Integral Frequency The total number of projections was 116928, FOV = 3 cm, matrix = 644, bw,max = 125 kHz, Ω = 18 kHz, Acq time = 15 min

  11. Applications of spectroscopic SWIFT • Short T2 map • Susceptibility map • B0 map • Spectroscopic imaging of metabolites

  12. More SWIFT from CMRR 2773. Enhancing Lipid Signals with SWIFT 2672. Implementation of SWIFT on a Siemens Clinical Scanner 2864. Iterative Reconstruction for Off-Resonance Effects in SWIFT Imaging 3061. MP-SWIFT with Adiabatic Inversion Preparation for Quiet, B1.. 802. SWIFT Detection of SPIO Labeled Stem Cells Grafted in theMyocardium 848. The Ultrastructure of Bone Using Selective Saturation in SWIFT at 9.4 T Acknowledgments. NIH P41-RR008079, the Keck Foundation. MMF 3761-9236-07 Thanks to many others at the CMRR!

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