1 / 13

Thymic Maturation and Peripheral T-cell Activation: A Review

Explore the initial differentiation processes involved in thymic maturation and the activation of T-cells in the periphery. Understand the mechanisms of positive and negative selection, signal transduction, and co-stimulatory differences among Antigen Presenting Cells.

khansen
Download Presentation

Thymic Maturation and Peripheral T-cell Activation: A Review

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Review…

  2. Initial differen-tiation…='s “thymic matura-tion”

  3. Initial differen-tiation…c-Kit (receptor for stem cell growth factor)CD44(an adhesion molecule)CD25 ( chain of IL-2 receptor)

  4. Fundamental notion: Positive selection of thymocytes bearing receptors capable of binding self-MHC molecules which results in MHC restriction. Negative selection by elimination of thymocytes bearing high-affinity receptors for self-MHC molecules alone or self-antigen presented by self-MHC, which results in self-tolerance.

  5. Another fundamental notion… There are first “double negatives” (DN’s)… Then there are “double positives” (DP’s)…. DN and DP refer to the presence of CD4 and CD8

  6. The effect Note what’s happening and where

  7. Evidence for Positive selection & Negative selection

  8. Activation… in the periphery… some key events:

  9. “Overview” (!)

  10. Some common themes in signal transduction… • The involvement of receptors • The generation of second messengers • The action of protein kinases and phosphatases • The induced assembly of critical components of a signal transduction pathway • Cascades • The involvement of large and small G proteins • The default setting for signal transduction is OFF

  11. The co-stimulatory signal

  12. Co-Stimulatory Differences among Antigen Presenting Cells (APC’s)

More Related